All Phenotypes Cd4<m1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd4^m1Btlr
mutation 1, Bruce Beutler
MGI:5582497

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd4^m1Btlr/Cd4^m1Btlr	C57BL/6J-Cd4^m1Btlr	MGI:5582500

Allelic Composition	Cd4^m1Btlr/Cd4^m1Btlr
Genetic Background	C57BL/6J-Cd4^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^m1Btlr mutation (1 available); any Cd4 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

absent CD4-positive, alpha-beta T cells ( J:212900 )

impaired humoral immune response ( J:212900 )

• mice lack T-dependent IgG responses to both aluminum hydroxide-emulsified ovalbumin (OVA) and recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase

hematopoietic system

absent CD4-positive, alpha-beta T cells ( J:212900 )

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