Phenotypes associated with this allele

• Allele Symbol: Ryr2^tm4.1Amks
• Allele Name: targeted mutation 4.1, Andrew R Marks
• Allele ID: MGI:5582511
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ryr2^tm4.1Amks/Ryr2^+	involves: 129 * C57BL/6	MGI:5582594

Genotype
MGI:5582594

ht1

• Allelic Composition: Ryr2^tm4.1Amks/Ryr2⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:212640 )

• leaky calcium channels in the sarcoplasmic reticulum of atrial myocytes

atrial fibrillation ( J:212640 )

• induced by atrial burst pacing in 5 of 14 mice

muscle

abnormal myocardial fiber morphology ( J:212640 )

• leaky calcium channels in the sarcoplasmic reticulum of atrial myocytes

abnormal sarcoplasmic reticulum morphology ( J:212640 )

• leaky calcium channels in the sarcoplasmic reticulum of atrial myocytes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
catecholaminergic polymorphic ventricular tachycardia 1		DOID:0060675	OMIM:604772	J:212640