Analysis Tools|
Allele Symbol Allele Name Allele ID |
Shcbp1tm1c(EUCOMM)Wtsi targeted mutation 1c, Wellcome Trust Sanger Institute MGI:5582589 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• in 2 week old mice that are not injected with MOG peptide, T cell development is normal
• the fraction of absolute numbers of CD4+ and CD8+ T cells in spleen and lymph nodes is similar to controls
• percentages and numbers of thymic compartment subsets in 4-6 week old mice are similar to controls
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• reduced disease severity is observed in mice injected with MOG35-55 peptide as compared to MOG-injected wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• T cell development appears normal in 2 week old mice
• fraction of absolute numbers of CD4+ and CD8+ T cells in spleen and lymph nodes is similar to controls
• numbers and percentages of thymic compartment subsets in 4-6 week old mice are similar to controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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