Phenotypes associated with this allele

• Allele Symbol: Shcbp1^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:5582592
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shcbp1^tm1d(EUCOMM)Wtsi/Shcbp1^tm1d(EUCOMM)Wtsi	involves: C57BL/6N * FVB/N	MGI:5582919

Genotype
MGI:5582919

hm1

• Allelic Composition: Shcbp1^{tm1d(EUCOMM)Wtsi}/Shcbp1^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:212898 )

N • in mice that are not injected with MOG peptide, thymic cellularity and appearance are similar to controls

N • normal ratios of CD4+ and CD8+ thymocytes

N • fractions of absolute numbers of CD4+ and CD8+ T cells in spleen and lymph nodes are similar to controls

decreased B cell number ( J:212898 )

• mice injected with MOG_35-55 peptide have fewer B cells as compared to controls

decreased T cell number ( J:212898 )

• mice injected with MOG_35-55 peptide have fewer CD3+ T cells in their spinal cords as compared to controls

decreased CD4-positive, alpha-beta T cell number ( J:212898 )

• mice injected with MOG_35-55 peptide have fewer CD4+ T cells as compared to controls

decreased macrophage cell number ( J:212898 )

• mice injected with MOG_35-55 peptide have fewer macrophages as compared to controls

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:212898 )

• reduced disease severity and improved survival is observed in mice injected with MOG_35-55 peptide as compared to MOG-injected wild-type mice

hematopoietic system

decreased B cell number ( J:212898 )

• mice injected with MOG_35-55 peptide have fewer B cells as compared to controls

decreased T cell number ( J:212898 )

• mice injected with MOG_35-55 peptide have fewer CD3+ T cells in their spinal cords as compared to controls

decreased CD4-positive, alpha-beta T cell number ( J:212898 )

• mice injected with MOG_35-55 peptide have fewer CD4+ T cells as compared to controls

decreased macrophage cell number ( J:212898 )

• mice injected with MOG_35-55 peptide have fewer macrophages as compared to controls