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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		TnfM2Btlr
mutation 2, Bruce Beutler
MGI:5582740
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		TnfM2Btlr/Tnf+ C57BL/6J-TnfM2Btlr MGI:5582754


Genotype
MGI:5582754
ht1
Allelic
Composition		 TnfM2Btlr/Tnf+
Genetic
Background		 C57BL/6J-TnfM2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
TnfM2Btlr mutation (1 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage cytokine production ( J:213047 )
• decreased TNFalpha secretion in response to Toll-like receptor (TLR) ligands, LPS (TLR4) and R848 (TLR7/8)
decreased tumor necrosis factor secretion ( J:213047 )
• decreased TNFalpha secretion in response to Toll-like receptor (TLR) ligands, LPS (TLR4) and R848 (TLR7/8)

hematopoietic system
decreased macrophage cytokine production ( J:213047 )
• decreased TNFalpha secretion in response to Toll-like receptor (TLR) ligands, LPS (TLR4) and R848 (TLR7/8)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory