Phenotypes associated with this allele

• Allele Symbol: Cnbd2^tm1Dwac
• Allele Name: targeted mutation 1, Dagmar Wachten
• Allele ID: MGI:5582743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnbd2^tm1Dwac/Cnbd2^tm1Dwac	B6.Cg-Cnbd2^tm1Dwac	MGI:5582744

Genotype
MGI:5582744

hm1

• Allelic Composition: Cnbd2^tm1Dwac/Cnbd2^tm1Dwac
• Genetic Background: B6.Cg-Cnbd2^tm1Dwac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm midpiece morphology ( J:207897 )

♂ • bent

♂ • whether non-capacitated or capacitated, flagellum remain in the anti-hook conformation

♂ • however, axoneme structure is normal

azoospermia ( J:207897 )

♂ • in mice with small testis

arrest of male meiosis ( J:207897 )

♂ • no haploid cells are produced in mice with small testis

abnormal sperm motility ( J:207897 )

♂ • reduced velocity of straight-line path under non-capacitating or capacitating conditions

abnormal testis morphology ( J:207897 )

♂ • in mice with small testis

♂ • however, mice with normal testis weight exhibit normal testis morphology

small seminiferous tubules ( J:207897 )

♂ • in mice with small testis

abnormal testis weight ( J:207897 )

♂ • variable

small testis ( J:207897 )

♂ • in some mice

decreased testis weight ( J:207897 )

♂ • in some mice

male infertility ( J:207897 )

♂ • in mice with small testis

reduced male fertility ( J:207897 )

♂ • in mice with normal testis size and morphology

♂ • however, in vitro fertilization rates are normal

cellular

abnormal sperm midpiece morphology ( J:207897 )

♂ • bent

♂ • whether non-capacitated or capacitated, flagellum remain in the anti-hook conformation

♂ • however, axoneme structure is normal

azoospermia ( J:207897 )

♂ • in mice with small testis

arrest of male meiosis ( J:207897 )

♂ • no haploid cells are produced in mice with small testis

abnormal sperm motility ( J:207897 )

♂ • reduced velocity of straight-line path under non-capacitating or capacitating conditions

abnormal motile cilium physiology ( J:207897 )

♂ • highly asymmetrical flagellar waveform from sperm associated with altered calcium regulation

♂ • in capacitated sperm, the asymmetry of the flagellar waveform is enhanced compared to in wild-type sperm

endocrine/exocrine glands

abnormal testis morphology ( J:207897 )

♂ • in mice with small testis

♂ • however, mice with normal testis weight exhibit normal testis morphology

small seminiferous tubules ( J:207897 )

♂ • in mice with small testis

abnormal testis weight ( J:207897 )

♂ • variable

small testis ( J:207897 )

♂ • in some mice

decreased testis weight ( J:207897 )

♂ • in some mice