Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(B4galt1)Clib}
• Allele Name: targeted mutation 1, Claude Libert
• Allele ID: MGI:5582802
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(B4galt1)Clib/Gt(ROSA)26Sor^tm1(B4galt1)Clib Tg(Nes-cre)Wme/?	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:5582815

Genotype
MGI:5582815

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(B4galt1)Clib}/Gt(ROSA)26Sor^{tm1(B4galt1)Clib}; Tg(Nes-cre)Wme/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:209737 )

• mice exhibit resistance to TNF-induced inflammatory shock with increased survival compared with control mice

digestive/alimentary system

digestive/alimentary phenotype ( J:209737 )

N • mice exhibit normal gut mucosa morphology

abnormal Paneth cell morphology ( J:209737 )

• reduced granule content

abnormal gut flora balance ( J:209737 )

• higher Firmicutes to Bacteroidetes ratio

decreased susceptibility to induced colitis ( J:209737 )

• DSS-treated mice exhibit less severe colitis symptoms (reduced rectal bleeding, diarrhea, colon shortening and increase in gut permeability without loss of crypt architecture or reduction in goblet cells) compared with control mice

immune system

decreased susceptibility to induced colitis ( J:209737 )

• DSS-treated mice exhibit less severe colitis symptoms (reduced rectal bleeding, diarrhea, colon shortening and increase in gut permeability without loss of crypt architecture or reduction in goblet cells) compared with control mice

decreased circulating interleukin-6 level ( J:209737 )

• in TNF-injected mice

decreased acute inflammation ( J:209737 )

• mice exhibit resistance to TNF-induced inflammatory shock with increased survival, faster recovery from initial drop in body temperature and reduced serum IL6 levels compared with control mice

• however, infiltration capacity of leukocytes is not altered

homeostasis/metabolism

abnormal homeostasis ( J:209737 )

• mice exhibit increase in galactose terminating N-glycans in ileum and colon mucus compared with control mice

decreased circulating interleukin-6 level ( J:209737 )

• in TNF-injected mice

hematopoietic system

hematopoietic system phenotype ( J:209737 )

N • mice exhibit normal blood composition

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:209737 )

• reduced granule content