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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Endoutm1Tft
targeted mutation 1, Thomas F Tedder
MGI:5582894
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Endoutm1Tft/Endoutm1Tft involves: 129S/SvEv * C57BL/6 MGI:5582911
cx2
 		Cd22tm2Tft/Cd22tm2Tft
Endoutm1Tft/Endoutm1Tft 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5582907
cx3
 		Endoutm1Tft/Endoutm1Tft
Tg(IghelMD4)4Ccg/0
Tg(ML5sHEL)5Ccg/0 		involves: 129S/SvEv * C57BL/6 * C57BL/6JSfd MGI:5582909


Genotype
MGI:5582911
hm1
Allelic
Composition		 Endoutm1Tft/Endoutm1Tft
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Endoutm1Tft mutation (0 available); any Endou mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:208364 )
N
• mice exhibit normal splenic B cell numbers and activation-induced B cell apoptosis




Genotype
MGI:5582907
cx2
Allelic
Composition		 Cd22tm2Tft/Cd22tm2Tft
Endoutm1Tft/Endoutm1Tft
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm2Tft mutation (1 available); any Cd22 mutation (64 available)
Endoutm1Tft mutation (0 available); any Endou mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:208364 )
N
• splenic B cell numbers are restored and reversed activation-induced B cell apoptosis with normal BCR-induced blast development and proliferation compared to in Cd22tm2Tft homozygotes
• the splenic B cell anergy phenotype observed in Cd22tm2Tft homozygotes is rescued




Genotype
MGI:5582909
cx3
Allelic
Composition		 Endoutm1Tft/Endoutm1Tft
Tg(IghelMD4)4Ccg/0
Tg(ML5sHEL)5Ccg/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * C57BL/6JSfd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Endoutm1Tft mutation (0 available); any Endou mutation (29 available)
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(ML5sHEL)5Ccg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:208364 )
N
• B cell phenotypes observed in Tg(IghelMD4)4Ccg Tg(ML5sHEL)5Ccg mice are normalized
decreased activation-induced B cell apoptosis ( J:208364 )
• absent in high responder mice
increased autoantibody level ( J:208364 )
• increased anti-HEL auto-antibody production compared with control mice

cellular
decreased activation-induced B cell apoptosis ( J:208364 )
• absent in high responder mice

hematopoietic system
decreased activation-induced B cell apoptosis ( J:208364 )
• absent in high responder mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory