Phenotypes associated with this allele

• Allele Symbol: Tg(HCRT-tTA)G5Ahky
• Allele Name: transgene insertion G5, Akihiro Yamanaka
• Allele ID: MGI:5582928
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Htr1a^tm3.1Rhn/? Tg(HCRT-tTA)G5Ahky/0	B6.Cg-Htr1a^tm3.1Rhn Tg(HCRT-tTA)G5Ahky	MGI:5582938

Genotype
MGI:5582938

cx1

• Allelic Composition: Htr1a^tm3.1Rhn/?; Tg(HCRT-tTA)G5Ahky/0
• Genetic Background: B6.Cg-Htr1a^tm3.1Rhn Tg(HCRT-tTA)G5Ahky

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal sleep duration ( J:212974 )

• the mean wakefulness bout duration is shortened

abnormal sleep pattern ( J:212974 )

• however, the sleep/wakefulness pattern during the light period is not affected

• the transition frequency between wakefulness and sleep is increased in the first 3 hours of the dark period

• in the presence of DOX, mice show normal sleep/wakefulness patterns

increased slow-wave sleep duration ( J:212974 )

• total amounts of slow wave sleep are increased during the first 6 hours of the dark period

• however, mean slow wave sleep bout durations are unaffected

increased frequency of paradoxical sleep ( J:212974 )

• total amounts of REM sleep are increased during the first 6 hours of the dark period

fragmentation of sleep/wake states ( J:212974 )

• mice show severe fragmentation of wakefulness during the first half of the dark period, with a decrease in total time in wakefulness