Phenotypes associated with this allele

• Allele Symbol: B4gat1^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5583065
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	B4gat1^tm1.1(KOMP)Vlcg/B4gat1^tm1.1(KOMP)Vlcg	C57BL/6N-B4gat1^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:6325115
hm2	B4gat1^tm1.1(KOMP)Vlcg/B4gat1^tm1.1(KOMP)Vlcg	C57BL/6NCrl-B4gat1^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:7751919
ht3	B4gat1^tm1.1(KOMP)Vlcg/B4gat1^+	C57BL/6NCrl-B4gat1^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:7751918

Genotype
MGI:6325115

hm1

• Allelic Composition: B4gat1^{tm1.1(KOMP)Vlcg}/B4gat1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-B4gat1^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 12887A-G3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

B4gat1^{tm1.1(KOMP)Vlcg}/B4gat1^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are present in expected Mendelian ratios at E7.5; no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

decreased egg cylinder size ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

Genotype
MGI:7751919

hm2

• Allelic Composition: B4gat1^{tm1.1(KOMP)Vlcg}/B4gat1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6NCrl-B4gat1^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 12887A-G3

Data Sources

IMPC Data for B4gat1

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:7751918

ht3

• Allelic Composition: B4gat1^{tm1.1(KOMP)Vlcg}/B4gat1⁺
• Genetic Background: C57BL/6NCrl-B4gat1^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 12887A-G3

Data Sources

IMPC Data for B4gat1

behavior/neurological

hyperactivity ( J:211773 )

♀

IMPC - UCD