Phenotypes associated with this allele

• Allele Symbol: Ranbp2^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5583083
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ranbp2^tm1.1(KOMP)Vlcg/Ranbp2^tm1.1(KOMP)Vlcg	C57BL/6N-Ranbp2^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:6325173
ht2	Ranbp2^tm1.1(KOMP)Vlcg/Ranbp2^+	C57BL/6N-Ranbp2^tm1.1(KOMP)Vlcg/MbpMmucd	MGI:5887495

Genotype
MGI:6325173

hm1

• Allelic Composition: Ranbp2^{tm1.1(KOMP)Vlcg}/Ranbp2^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Ranbp2^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 14451B-F6

Data Sources

IMPC Data for Ranbp2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ranbp2^{tm1.1(KOMP)Vlcg}/Ranbp2^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulae. Mutants fail to hatch from the zona pellucida and never reach blastocyst stage in culture.

embryo

failure of blastocyst formation ( J:279207 )

• in vitro, embryos show no further development and never reach a morphological blastocyst stage after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, embryos fail to hatch from the zona pellucida after 3 days in culture

abnormal morula morphology ( J:279207 )

• embryos recovered at E3.5 appear as dying morulae

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at slightly lower than expected Mendelian ratios at E3.5 (7% versus expected 25%, n=46) and appear as dying morulae; no homozygous embryos or excess resorption sites are observed at E7.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

Genotype
MGI:5887495

ht2

• Allelic Composition: Ranbp2^{tm1.1(KOMP)Vlcg}/Ranbp2⁺
• Genetic Background: C57BL/6N-Ranbp2^{tm1.1(KOMP)Vlcg}/MbpMmucd
• Cell Lines: 14451B-F6

Data Sources

IMPC Data for Ranbp2

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

abnormal epididymis morphology ( J:211773 )

♂

IMPC - UCD

enlarged epididymis ( J:211773 )

♂

IMPC - UCD