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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gde1tm1Crv
targeted mutation 1, Benjamin F Cravatt
MGI:5583864
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gde1tm1Crv/Gde1tm1Crv involves: C57BL/6 MGI:5583869
cx2
 		Gde1tm1Crv/Gde1tm1Crv
Napepldtm1Crv/Napepldtm1Crv 		involves: 129X1/SvJ * C57BL/6 MGI:5583870


Genotype
MGI:5583869
hm1
Allelic
Composition		 Gde1tm1Crv/Gde1tm1Crv
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gde1tm1Crv mutation (0 available); any Gde1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:213193 )
• brain homogenates lack glycero-phospho-N-acyl ethanolamine (GP-NAE) phosphodiesterase activity
• however, arachidonoyl ethanolamine and N-acyl ethanolamine bulk levels in the brain are normal




Genotype
MGI:5583870
cx2
Allelic
Composition		 Gde1tm1Crv/Gde1tm1Crv
Napepldtm1Crv/Napepldtm1Crv
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gde1tm1Crv mutation (0 available); any Gde1 mutation (21 available)
Napepldtm1Crv mutation (0 available); any Napepld mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:213193 )
• brain homogenates lack conversion of N-acyl phosphatidyl ethanolamine to N-acyl ethanolamine
• treatment with an FAAH inhibitor fail to result in accumulation N-acyl ethanolamine in the brain
• however, N-acyl ethanolamine bulk levels in the brain is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory