Phenotypes associated with this allele

• Allele Symbol: Chat^tm1Mlt
• Allele Name: targeted mutation 1, Jacques Mallet
• Allele ID: MGI:5583868
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chat^tm1Mlt/Chat^tm1Mlt Tg(SLC18A3-cre)KMisa/0	involves: 129 * C57BL/6	MGI:5585431

Genotype
MGI:5585431

cn1

• Allelic Composition: Chat^tm1Mlt/Chat^tm1Mlt; Tg(SLC18A3-cre)KMisa/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:212048 )

• shorter life span than control animals from 5 months of age

limbs/digits/tail

abnormal gastrocnemius morphology ( J:212048 )

• fibrosis accumulation at 4 months of age

abnormal soleus morphology ( J:212048 )

• fibrosis accumulation at 4 months of age

abnormal tail morphology ( J:212048 )

• tail distortion

skeleton

kyphosis ( J:212048 )

• spinal curve at the level of the thoracic vertebrae

behavior/neurological

abnormal habituation to a new environment ( J:212048 )

tremors ( J:212048 )

tail dragging ( J:212048 )

• in half the animals older than 1 year

abnormal gait ( J:212048 )

• abnormal walk posture (waddling gait)

decreased vertical activity ( J:212048 )

• rearing is severely affected in 6 to 18 months old animals

decreased locomotor activity ( J:212048 )

• spontaneous locomotor activities decreased in 6 to 18 months old animals

nervous system

nervous system phenotype ( J:212048 )

N • normal motor neuron survival in 3 months old animals

growth/size/body

decreased body weight ( J:212048 )

• significantly decreased from 11 months for females and from 4 months of age for males

digestive/alimentary system

rectal prolapse ( J:212048 )

• in half the animals older than 1 year

vision/eye

cornea opacity ( J:212048 )

• in half the animals older than 1 year

muscle

abnormal muscle morphology ( J:212048 )

• decreased proportion of type-I myofibers

abnormal gastrocnemius morphology ( J:212048 )

• fibrosis accumulation at 4 months of age

abnormal soleus morphology ( J:212048 )

• fibrosis accumulation at 4 months of age

skeletal muscle fibrosis ( J:212048 )

• in soleus and gastrocnemius muscle at 4 months of age

skeletal muscle endomysial fibrosis ( J:212048 )

• with incidence and severity worsened with aging

muscular atrophy ( J:212048 )

• progressive muscle fiber atrophy in diaphragm, intercostal, paravertebral, and limb muscles at 17 months of age

muscle weakness ( J:212048 )

• significant decreased time spent on inverted grid test and decreased ability to hold grids of varying weights in 6 to 18 months old animals