Phenotypes associated with this allele

• Allele Symbol: Mecp2^tm1.1Dhy
• Allele Name: targeted mutation 1.1, Dag H Yasui
• Allele ID: MGI:5584016
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mecp2^tm1.1Dhy/Mecp2^+	C57BL/6N-Mecp2^tm1.1Dhy	MGI:5584026
ot2	Mecp2^tm1.1Dhy/Y	C57BL/6N-Mecp2^tm1.1Dhy	MGI:5584025

Genotype
MGI:5584026

ht1

• Allelic Composition: Mecp2^tm1.1Dhy/Mecp2⁺
• Genetic Background: C57BL/6N-Mecp2^tm1.1Dhy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:209069 )

♀ • at 30 weeks, mice exhibit mild neurological defects (determined by scoring of level of grooming, ambulation, presence of skin sores, abdomen size and response to tail suspension) as in Mecp2^tm1.1Bird mice

limb grasping ( J:209069 )

♀ • delayed hind limb clasping

growth/size/body

growth/size/body region phenotype ( J:209069 )

♀N • mice exhibit normal weight, body length and body mass index

Genotype
MGI:5584025

ot2

• Allelic Composition: Mecp2^tm1.1Dhy/Y
• Genetic Background: C57BL/6N-Mecp2^tm1.1Dhy

mortality/aging

premature death ( J:209069 )

♂ • mice die between 7 and 31 weeks

behavior/neurological

abnormal behavior ( J:209069 )

♂ • by 6 weeks, mice exhibit neurological defects (determined by scoring of level of grooming, ambulation, presence of skin sores, abdomen size and response to tail suspension) as in Mecp2^tm1.1Bird mice

decreased anxiety-related response ( J:209069 )

♂ • in an elevated plus maze, mice spend more time in the open arms compared with wild-type mice

increased grooming behavior ( J:209069 )

♂ • stereotypic over grooming

abnormal gait ( J:209069 )

♂ • mice exhibit slower running pace and reduced variability in rear paw placement distance compared with wild-type mice

abnormal social investigation ( J:209069 )

♂ • in a three-chambered assay, mice spend less time interacting with a test mice compared with wild-type mice

seizures ( J:209069 )

♂ • possible seizure activity

nervous system

seizures ( J:209069 )

♂ • possible seizure activity

abnormal hippocampus neuron morphology ( J:209069 )

♂ • smaller nuclei than in wild-type mice

integument

focal hair loss ( J:209069 )

♂ • on flanks, chest and tail region

skin lesions ( J:209069 )

♂ • skin loss on flanks, chest and tail region

growth/size/body

growth/size/body region phenotype ( J:209069 )

♂N • mice exhibit normal weight, body length and body mass index

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:209069