Phenotypes associated with this allele

• Allele Symbol: Gng8^tm1(tTA)Rtir
• Allele Name: targeted mutation 1, Roberto Tirindelli
• Allele ID: MGI:5584308
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gng8^tm1(tTA)Rtir/Gng8^tm1(tTA)Rtir	FVB.129-Gng8^tm1(tTA)Rtir	MGI:5584309

Genotype
MGI:5584309

hm1

• Allelic Composition: Gng8^tm1(tTA)Rtir/Gng8^tm1(tTA)Rtir
• Genetic Background: FVB.129-Gng8^tm1(tTA)Rtir

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased aggression towards male mice ( J:212780 )

• lactating female mice exhibit reduced aggressive behavior towards male intruders compared with wild-type mice

• 3 month old mice exhibit less aggressive behavior towards the same-sex intruder compared with wild-type mice

abnormal voluntary movement ( J:212780 )

• somewhat lower levels of sniffing behavior

decreased vertical activity ( J:212780 )

• somewhat

increased locomotor activity ( J:212780 )

• somewhat higher level of horizontal locomotion (walking) compared with wild-type mice

abnormal maternal behavior ( J:212780 )

♀ • lactating female mice exhibit reduced aggressive behavior towards male intruders compared with wild-type mice

abnormal social investigation ( J:212780 )

♂ • male mice exhibit increased social investigation towards the same-sex intruder mouse compared with wild-type mice

craniofacial

abnormal vomeronasal sensory neuron morphology ( J:212780 )

• decreased basal neuron numbers at 3 weeks of age

• however, the number of A3+ neurons is normal at 6 weeks

growth/size/body

abnormal vomeronasal sensory neuron morphology ( J:212780 )

• decreased basal neuron numbers at 3 weeks of age

• however, the number of A3+ neurons is normal at 6 weeks

nervous system

abnormal vomeronasal sensory neuron morphology ( J:212780 )

• decreased basal neuron numbers at 3 weeks of age

• however, the number of A3+ neurons is normal at 6 weeks

abnormal accessory olfactory bulb morphology ( J:212780 )

• reduced posterior glomerular layer with loss of chemosensory neurons

respiratory system

abnormal vomeronasal sensory neuron morphology ( J:212780 )

• decreased basal neuron numbers at 3 weeks of age

• however, the number of A3+ neurons is normal at 6 weeks

taste/olfaction

taste/olfaction phenotype ( J:212780 )

N • mice exhibit normal olfactory function in a buried food test and gross olfactory system anatomy