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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gja1tm3.1Clo
targeted mutation 3.1, Cecilia Lo
MGI:5584311
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gja1tm3.1Clo/Gja1tm3.1Clo B6.Cg-Gja1tm1.1Clo MGI:5584312


Genotype
MGI:5584312
hm1
Allelic
Composition		 Gja1tm3.1Clo/Gja1tm3.1Clo
Genetic
Background		 B6.Cg-Gja1tm1.1Clo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja1tm3.1Clo mutation (1 available); any Gja1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular smooth muscle cell proliferation ( J:212895 )
• treatment of carotids with PDGF does not produce increases in vascular smooth muscle cell proliferation as seen in wild-type carotids
abnormal vascular wound healing ( J:212895 )
• carotids from ligated mice shows reduced neointima formation compared to wild-type mice

cellular
abnormal vascular smooth muscle cell proliferation ( J:212895 )
• treatment of carotids with PDGF does not produce increases in vascular smooth muscle cell proliferation as seen in wild-type carotids

homeostasis/metabolism
abnormal vascular wound healing ( J:212895 )
• carotids from ligated mice shows reduced neointima formation compared to wild-type mice

muscle
abnormal vascular smooth muscle cell proliferation ( J:212895 )
• treatment of carotids with PDGF does not produce increases in vascular smooth muscle cell proliferation as seen in wild-type carotids




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory