Phenotypes associated with this allele

• Allele Symbol: Fpr3^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5584405
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fpr3^tm1b(EUCOMM)Hmgu/Fpr3^tm1b(EUCOMM)Hmgu	C57BL/6N-Fpr3^tm1b(EUCOMM)Hmgu/Ics	MGI:5757133
hm2	Fpr3^tm1b(EUCOMM)Hmgu/Fpr3^tm1b(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6379588

Genotype
MGI:5757133

hm1

• Allelic Composition: Fpr3^{tm1b(EUCOMM)Hmgu}/Fpr3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Fpr3^{tm1b(EUCOMM)Hmgu}/Ics
• Cell Lines: HEPD0729_7_D10

Data Sources

IMPC Data for Fpr3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - ICS

digestive/alimentary system

abnormal colon morphology ( J:211773 )

♂

IMPC - ICS

abnormal ileum morphology ( J:211773 )

♂

IMPC - ICS

hematopoietic system

increased hematocrit ( J:211773 )

♂

IMPC - ICS

increased hemoglobin content ( J:211773 )

♂

IMPC - ICS

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - ICS

vision/eye

abnormal vitreous body morphology ( J:211773 )

IMPC - ICS

persistence of hyaloid vascular system ( J:211773 )

IMPC - ICS

Genotype
MGI:6379588

hm2

• Allelic Composition: Fpr3^{tm1b(EUCOMM)Hmgu}/Fpr3^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N
• Cell Lines: HEPD0729_7_D10

behavior/neurological

abnormal behavior ( J:279957 )

♂ • due to the lack of vomeronasal perception of f-MKKFRW, homozygotes fail to display the normal avoidance behaviour to this core peptide of an enteric bacterial virulence regulator

nervous system

abnormal vomeronasal sensory neuron physiology ( J:279957 )

• Rhod-2 confocal calcium imaging in mice lacking Fpr3 shows a failure to respond to f-MKKFRW peptide, the core peptide motif from MgrB, which is the enteric bacterial master virulence regulator