Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-Mir184)4Mnpy
• Allele Name: transgene insertion 4, Matthew N Poy
• Allele ID: MGI:5585172
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lep^ob/Lep^ob Tg(Ins2-Mir184)4Mnpy/0	involves: C57BL/10J	MGI:5585182
tg2	Tg(Ins2-Mir184)4Mnpy/0	Not Specified	MGI:5585180

Genotype
MGI:5585182

cx1

• Allelic Composition: Lep^ob/Lep^ob; Tg(Ins2-Mir184)4Mnpy/0
• Genetic Background: involves: C57BL/10J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:210552 )

• compared with Lep^ob homozygotes

hyperglycemia ( J:210552 )

• severe compared with Lep^ob homozygotes

decreased circulating insulin level ( J:210552 )

• compared with Lep^ob homozygotes

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:210552 )

• compared with Lep^ob homozygotes

decreased insulin secretion ( J:210552 )

• compared with Lep^ob homozygotes

growth/size/body

decreased body weight ( J:210552 )

• compared with Lep^ob homozygotes

weight loss ( J:210552 )

• ultimately compared with Lep^ob homozygotes

Genotype
MGI:5585180

tg2

• Allelic Composition: Tg(Ins2-Mir184)4Mnpy/0
• Genetic Background: Not Specified

homeostasis/metabolism

decreased insulin secretion ( J:210552 )

hyperglycemia ( J:210552 )

• severe

decreased circulating insulin level ( J:210552 )

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:210552 )

decreased pancreatic beta cell mass ( J:210552 )

decreased insulin secretion ( J:210552 )

growth/size/body

decreased body weight ( J:210552 )

cellular

decreased pancreatic beta cell proliferation ( J:210552 )