Phenotypes associated with this allele

• Allele Symbol: Mir22^tm1.2Dzw
• Allele Name: targeted mutation 1.1, Da-Zhi Wang
• Allele ID: MGI:5585450
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir22^tm1.2Dzw/Mir22^tm1.2Dzw	involves: C57BL/6	MGI:5585453
cx2	Mir22^tm1.2Dzw/Mir22^tm1.2Dzw Tg(Myh6-Ppp3ca)37Eno/0	involves: C57BL/6 * FVB	MGI:5585456

Genotype
MGI:5585453

hm1

• Allelic Composition: Mir22^tm1.2Dzw/Mir22^tm1.2Dzw
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:213308 )

N • mice are viable and fertile and exhibit normal cardiac morphology and echocardiographic measures of left ventricular size and function under basal conditions

decreased response of heart to induced stress ( J:213308 )

• the cardiac hypertrophic response to chronic infusion of the Beta-agonist isoproterenol is reduced in mutant hearts, with mice showing a decrease in ventricular wall thickness, an increase in ventricular chamber size, and a decrease in size of cardiomyocytes compared to wild-type mice

• ventricular contraction is decreased in response to isoproterenol compared to wild-type hearts

increased response of heart to induced stress ( J:213308 )

• mice show increased sensitivity to the development of dilated cardiomyopathy in response to the Beta-agonist isoproterenol, showing increased left ventricle internal dimension and volume

• mice show increased cardiac fibrosis and apoptosis in the heart in response to isoproterenol compared to controls

homeostasis/metabolism

decreased response of heart to induced stress ( J:213308 )

• the cardiac hypertrophic response to chronic infusion of the Beta-agonist isoproterenol is reduced in mutant hearts, with mice showing a decrease in ventricular wall thickness, an increase in ventricular chamber size, and a decrease in size of cardiomyocytes compared to wild-type mice

• ventricular contraction is decreased in response to isoproterenol compared to wild-type hearts

increased response of heart to induced stress ( J:213308 )

• mice show increased sensitivity to the development of dilated cardiomyopathy in response to the Beta-agonist isoproterenol, showing increased left ventricle internal dimension and volume

• mice show increased cardiac fibrosis and apoptosis in the heart in response to isoproterenol compared to controls

Genotype
MGI:5585456

cx2

• Allelic Composition: Mir22^tm1.2Dzw/Mir22^tm1.2Dzw; Tg(Myh6-Ppp3ca)37Eno/0
• Genetic Background: involves: C57BL/6 * FVB

cardiovascular system

cardiac hypertrophy ( J:213308 )

• dramatic cardiac hypertrophy as indicated by an increase in heart weight to body weight ratio at 1 month of age that is similar to single Tg(Myh6-Ppp3ca)37Eno mice

abnormal heart ventricle wall thickness ( J:213308 )

• thickening of the left ventricle free wall and septum are decreased compared to single Tg(Myh6-Ppp3ca)37Eno mice

cardiac fibrosis ( J:213308 )

• mice show an increase in cardiac fibrosis compared to single Tg(Myh6-Ppp3ca)37Eno mice

growth/size/body

cardiac hypertrophy ( J:213308 )

• dramatic cardiac hypertrophy as indicated by an increase in heart weight to body weight ratio at 1 month of age that is similar to single Tg(Myh6-Ppp3ca)37Eno mice