Phenotypes associated with this allele

• Allele Symbol: Sucla2^{Gt(SAbetageo)1Bhg}
• Allele Name: gene trap 1, Brett H Graham
• Allele ID: MGI:5585619
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sucla2^Gt(SAbetageo)1Bhg/Sucla2^Gt(SAbetageo)1Bhg	involves: 129S6/SvEvTac * C57BL/6	MGI:5585620
ht2	Sucla2^Gt(SAbetageo)1Bhg/Sucla2^+	involves: 129S6/SvEvTac * C57BL/6	MGI:5585621

Genotype
MGI:5585620

hm1

• Allelic Composition: Sucla2^{Gt(SAbetageo)1Bhg}/Sucla2^{Gt(SAbetageo)1Bhg}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:213453 )

• mice die at or after E18.5 with no mice are born alive

cellular

abnormal mitochondrial morphology ( J:213453 )

• mouse embryonic fibroblasts exhibit mitochondria depolarization compared with wild-type cells

decreased mitochondrial DNA content ( J:213453 )

• in placenta, brain and muscle cells at E17.5

• progressive in mouse embryonic fibroblasts

increased mitochondrial DNA content ( J:213453 )

• increased mitochondrial DNA in the brain and muscle at E15.5 and in mouse embryonic fibroblasts during the first week of culture

abnormal mitochondrial physiology ( J:213453 )

• perturbed mitochondria respiration in mouse embryonic fibroblasts

embryo

abnormal placenta morphology ( J:213453 )

• signs of placenta mineralization at E17.5

growth/size/body

decreased fetal size ( J:213453 )

• at E17.5

Genotype
MGI:5585621

ht2

• Allelic Composition: Sucla2^{Gt(SAbetageo)1Bhg}/Sucla2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

cellular

increased mitochondrial DNA content ( J:213453 )

• increased mitochondrial DNA in mouse embryonic fibroblasts during the first week of culture

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mitochondrial DNA depletion syndrome 5		DOID:0080124	OMIM:612073	J:213453