All Phenotypes Kmt2d<tm1.1Kaig> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kmt2d^tm1.1Kaig
targeted mutation 1.1, Kai Ge
MGI:5585624

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Tmem163^{Tg(ACTB-cre)2Mrt}/0	B6.Cg-Kmt2d^tm1.1Kaig Tg(ACTB-cre)2Mrt	MGI:5780091
cn2	Kmt2d^tm1.1Kaig/Kmt2d⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/0	B6.Cg-Kmt2d^tm1.1Kaig Tg(ACTB-cre)2Mrt	MGI:5780092
cn3	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Tg(Mef2c-cre)2Blk/0	B6.Cg-Kmt2d^tm1.1Kaig Tg(Mef2c-cre)2Blk	MGI:5780096
cn4	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Tg(Tnnt2-cre)5Blh/0	B6.Cg-Kmt2d^tm1.1Kaig Tg(Tnnt2-cre)5Blh	MGI:5780098
cn5	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Mesp1^tm2(cre)Ysa/Mesp1⁺	B6.Cg-Mesp1^tm2(cre)Ysa Kmt2d^tm1.1Kaig	MGI:5780094
cn6	Kmt2d^tm1.1Kaig/Kmt2d⁺ Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5780069
cn7	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Ighg1^tm1(cre)Cgn/Ighg1⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5780068
cn8	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5780067
cn9	Kmt2d^tm1.1Kaig/Kmt2d⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Tg(Vav-BCL2)69Jad/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:5780072
cn10	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Ighg1^tm1(cre)Cgn/Ighg1⁺ Tg(Vav-BCL2)69Jad/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:5780071
cn11	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Myf5^tm3(cre)Sor/Myf5⁺	involves: 129S4/SvJaeSor * C57BL/6J	MGI:5585627
cn12	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Tg(Nkx2-1-cre)2Sand/0	involves: C57BL/6	MGI:6515626

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Tmem163^{Tg(ACTB-cre)2Mrt}/0
Genetic Background	B6.Cg-Kmt2d^tm1.1Kaig Tg(ACTB-cre)2Mrt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2d^tm1.1Kaig mutation (1 available); any Kmt2d mutation (169 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:229890 )

• while present at E8.0, no mice are detected at E8.5 and beyond

embryo

absent head fold ( J:229890 )

• at E8.0

absent somites ( J:229890 )

• at E8.0

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/0
Genetic Background	B6.Cg-Kmt2d^tm1.1Kaig Tg(ACTB-cre)2Mrt

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:229890 )

N	• mice exhibit normal cardiac morphology and fractional shortening

abnormal heart echocardiography feature ( J:229890 )

• narrowing diameter of the ascending aorta

• increased aortic valve peak velocity

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Tg(Mef2c-cre)2Blk/0
Genetic Background	B6.Cg-Kmt2d^tm1.1Kaig Tg(Mef2c-cre)2Blk

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2d^tm1.1Kaig mutation (1 available); any Kmt2d mutation (169 available)
Tg(Mef2c-cre)2Blk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:229890 )

• while present at E11.5, mice die by E13.5

cardiovascular system

persistent truncus arteriosus ( J:229890 )

• at E12.5

abnormal interventricular septum morphology ( J:229890 )

• disorganized at E12.5

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Tg(Tnnt2-cre)5Blh/0
Genetic Background	B6.Cg-Kmt2d^tm1.1Kaig Tg(Tnnt2-cre)5Blh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2d^tm1.1Kaig mutation (1 available); any Kmt2d mutation (169 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:229890 )

• while present at E13.5, mice die by E14.5

cardiovascular system

cardiovascular system phenotype ( J:229890 )

N	• mice exhibit normal septation of outflow tract into the aorta and pulmonary artery

thin myocardium compact layer ( J:229890 )

• at E13.5

abnormal interventricular septum morphology ( J:229890 )

• disorganized

abnormal fetal cardiomyocyte physiology ( J:229890 )

• at E11.5, ventricular myocytes exhibit prolonged waveforms of calcium transients compared with control cells

decreased fetal cardiomyocyte proliferation ( J:229890 )

cellular

decreased fetal cardiomyocyte proliferation ( J:229890 )

muscle

thin myocardium compact layer ( J:229890 )

• at E13.5

decreased fetal cardiomyocyte proliferation ( J:229890 )

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Mesp1^tm2(cre)Ysa/Mesp1⁺
Genetic Background	B6.Cg-Mesp1^tm2(cre)Ysa Kmt2d^tm1.1Kaig

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2d^tm1.1Kaig mutation (1 available); any Kmt2d mutation (169 available)
Mesp1^tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:229890 )

• no mice are observed after E10.5

embryo

embryonic growth retardation ( J:229890 )

• at E10.5

cardiovascular system

abnormal heart tube morphology ( J:229890 )

• linear at E10.5

pericardial edema ( J:229890 )

• at E10.5

growth/size/body

embryonic growth retardation ( J:229890 )

• at E10.5

homeostasis/metabolism

pericardial edema ( J:229890 )

• at E10.5

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d⁺ Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Kmt2d^tm1.1Kaig mutation (1 available); any Kmt2d mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased germinal center B cell number ( J:228913 )

• intermediate at 3 and 6 months in mice immunized with sheep red blood cell

increased spleen germinal center size ( J:228913 )

• intermediate at 3 and 6 months in mice immunized with sheep red blood cell

hematopoietic system

increased germinal center B cell number ( J:228913 )

• intermediate at 3 and 6 months in mice immunized with sheep red blood cell

increased spleen germinal center size ( J:228913 )

• intermediate at 3 and 6 months in mice immunized with sheep red blood cell

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Ighg1^tm1(cre)Cgn/Ighg1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Kmt2d^tm1.1Kaig mutation (1 available); any Kmt2d mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:228913 )

N	• unimmunized mice exhibit normal germinal center size and number, IgG1+ B cell numbers, plasma cells, total IgG1 serum levels and induced B cell proliferation

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:228913 )

N	• unimmunized mice exhibit normal numbers of bone marrow B cell subpopulations, splenic follicular B cells and marginal zone B cells • mice immunized with sheep red blood cell exhibit normal numbers of transitional and marginal zone B cells

increased B cell proliferation ( J:228913 )

abnormal B cell differentiation ( J:228913 )

• modest impairment in affinity maturation

• however, somatic hypermutation is normal

increased germinal center B cell number ( J:228913 )

• 3-fold in the spleen and also in the mesenteric lymph nodes of mice immunized with sheep red blood cell

• in mice challenged with NP-KLH

decreased B cell number ( J:228913 )

• in the spleen and lymph nodes of mice immunized with sheep red blood cell

decreased mature B cell number ( J:228913 )

• in the bone marrow of mice immunized with sheep red blood cell

decreased follicular B cell number ( J:228913 )

increased spleen germinal center number ( J:228913 )

• in mice immunized with sheep red blood cell

• in mice challenged with NP-KLH

increased spleen germinal center size ( J:228913 )

• in mice immunized with sheep red blood cell

• in mice challenged with NP-KLH

decreased IgG1 level ( J:228913 )

• 10-fold less in mice challenged with NP-KLH

decreased IgM level ( J:228913 )

• 10-fold less in mice challenged with NP-KLH

hematopoietic system

increased B cell proliferation ( J:228913 )

abnormal B cell differentiation ( J:228913 )

• modest impairment in affinity maturation

• however, somatic hypermutation is normal

increased germinal center B cell number ( J:228913 )

• 3-fold in the spleen and also in the mesenteric lymph nodes of mice immunized with sheep red blood cell

• in mice challenged with NP-KLH

decreased B cell number ( J:228913 )

• in the spleen and lymph nodes of mice immunized with sheep red blood cell

decreased mature B cell number ( J:228913 )

• in the bone marrow of mice immunized with sheep red blood cell

decreased follicular B cell number ( J:228913 )

increased spleen germinal center number ( J:228913 )

• in mice immunized with sheep red blood cell

• in mice challenged with NP-KLH

increased spleen germinal center size ( J:228913 )

• in mice immunized with sheep red blood cell

• in mice challenged with NP-KLH

decreased IgG1 level ( J:228913 )

• 10-fold less in mice challenged with NP-KLH

decreased IgM level ( J:228913 )

• 10-fold less in mice challenged with NP-KLH

cellular

increased B cell proliferation ( J:228913 )

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Tg(Vav-BCL2)69Jad/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:228913 )

• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice

neoplasm

increased B cell derived lymphoma incidence ( J:228913 )

• diffuse large B cell lymphoma as in Tg(Vav-BCL2)1Jad mice

increased follicular lymphoma incidence ( J:228913 )

• more so than in Tg(Vav-BCL2)1Jad mice

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Ighg1^tm1(cre)Cgn/Ighg1⁺ Tg(Vav-BCL2)69Jad/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:228913 )

• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice

neoplasm

increased B cell derived lymphoma incidence ( J:228913 )

• diffuse large B cell lymphoma more so than in Tg(Vav-BCL2)1Jad mice

increased follicular lymphoma incidence ( J:228913 )

• more so than in Tg(Vav-BCL2)1Jad mice

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Myf5^tm3(cre)Sor/Myf5⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2d^tm1.1Kaig mutation (1 available); any Kmt2d mutation (169 available)
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:207891 )

• mice die immediately after birth due to breathing malfunction

adipose tissue

decreased brown adipose tissue amount ( J:207891 )

abnormal brown fat cell differentiation ( J:207891 )

• moderate defects in brown adipose tissue differentiation in vitro

muscle

abnormal muscle morphology ( J:207891 )

decreased muscle weight ( J:207891 )

respiratory system

respiratory failure ( J:207891 )

• at birth

cellular

abnormal brown fat cell differentiation ( J:207891 )

• moderate defects in brown adipose tissue differentiation in vitro

Allelic Composition	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Tg(Nkx2-1-cre)2Sand/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2d^tm1.1Kaig mutation (1 available); any Kmt2d mutation (169 available)
Tg(Nkx2-1-cre)2Sand mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

impaired neuron differentiation ( J:301083 )

• marker analysis suggests that the development of GHRH-neurons, rather than just the expression of Ghrh, is impaired in mutant mice

• however, the number of AgRP-neurons is unchanged and neither Sf1+ or Trh+ cell numbers are altered

decreased neuron number ( J:301083 )

• growth hormone-releasing hormone (GHRH)-producing neurons expressing Ghrh and Th are reduced at E14.5-E15.5, indicating that development of GHRH-neurons is impaired

• mice show a reduction of GHRH-neurons at P65

homeostasis/metabolism

decreased circulating glucose level ( J:301083 )

cellular

impaired neuron differentiation ( J:301083 )

• marker analysis suggests that the development of GHRH-neurons, rather than just the expression of Ghrh, is impaired in mutant mice

• however, the number of AgRP-neurons is unchanged and neither Sf1+ or Trh+ cell numbers are altered

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