Phenotypes associated with this allele

• Allele Symbol: Foxj1^{tm1.1(cre/ERT2/GFP)Htg}
• Allele Name: targeted mutation 1.1, H Troy Gashghaei
• Allele ID: MGI:5585638
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxj1^tm1.1(cre/ERT2/GFP)Htg/Foxj1^tm1.1(cre/ERT2/GFP)Htg	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr	MGI:5585641
hm2	Foxj1^tm1.1(cre/ERT2/GFP)Htg/Foxj1^tm1.1(cre/ERT2/GFP)Htg	STOCK Foxj1^tm1.1(cre/ERT2/GFP)Htg/J	MGI:7545539
cn3	Gas2l2^tm1c(KOMP)Wtsi/Gas2l2^tm1c(KOMP)Wtsi Foxj1^tm1.1(cre/ERT2/GFP)Htg/Foxj1^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N	MGI:6343406

Genotype
MGI:5585641

hm1

• Allelic Composition: Foxj1^{tm1.1(cre/ERT2/GFP)Htg}/Foxj1^{tm1.1(cre/ERT2/GFP)Htg}
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

situs inversus ( J:213359 )

nervous system

hydrocephaly ( J:213359 )

Genotype
MGI:7545539

hm2

• Allelic Composition: Foxj1^{tm1.1(cre/ERT2/GFP)Htg}/Foxj1^{tm1.1(cre/ERT2/GFP)Htg}
• Genetic Background: STOCK Foxj1^{tm1.1(cre/ERT2/GFP)Htg}/J

cardiovascular system

abnormal cardiac outflow tract development ( J:342078 )

• the outflow tract may be positioned on the left, middle, right middle or left/middle in 58% of embryos

abnormal heart morphology ( J:342078 )

• all hearts show some abnormalities with most showing combined abnormalities

abnormal heart looping ( J:342078 )

• looping defects in 41.5% of embryos

• dextrocardia in 24.4%, combined ventral/sinistral looping in 4.9%, and absence of looping or single ventricles in 3.4%

abnormal heart and great vessel attachment ( J:342078 )

• in some embryos the positioning of aorta pulmonary trunk are abnormal

double outlet right ventricle ( J:342078 )

double inlet heart left ventricle ( J:342078 )

increased heart atrium size ( J:342078 )

abnormal heart position or orientation ( J:342078 )

• atrial isomerism and inverted atria

dextrocardia ( J:342078 )

• in 24.4% of embryos

atrioventricular septal defect ( J:342078 )

ventricular septal defect ( J:342078 )

• show various subtypes of defects including inlet, outlet, perimembranous, and muscular

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital heart disease		DOID:1682		J:342078

Genotype
MGI:6343406

cn3

• Allelic Composition: Gas2l2^{tm1c(KOMP)Wtsi}/Gas2l2^{tm1c(KOMP)Wtsi}; Foxj1^{tm1.1(cre/ERT2/GFP)Htg}/Foxj1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

craniofacial

abnormal nasal cavity morphology ( J:277289 )

• about 80% of tamoxifen-treated mice exhibit increased nasal air space due to remodeling of the nasal cavity

• nasal air space increases over time and is significant at 2 and 3 months after tamoxifen treatment

abnormal paranasal sinus morphology ( J:277289 )

• about 80% of tamoxifen-treated mice develop mucus plugging in multiple nasal cavities

growth/size/body

abnormal nasal cavity morphology ( J:277289 )

• about 80% of tamoxifen-treated mice exhibit increased nasal air space due to remodeling of the nasal cavity

• nasal air space increases over time and is significant at 2 and 3 months after tamoxifen treatment

abnormal paranasal sinus morphology ( J:277289 )

• about 80% of tamoxifen-treated mice develop mucus plugging in multiple nasal cavities

nervous system

hydrocephaly ( J:277289 )

• about 3% of tamoxifen-treated mice exhibit hydrocephalus

respiratory system

abnormal nasal cavity morphology ( J:277289 )

• about 80% of tamoxifen-treated mice exhibit increased nasal air space due to remodeling of the nasal cavity

• nasal air space increases over time and is significant at 2 and 3 months after tamoxifen treatment

abnormal paranasal sinus morphology ( J:277289 )

• about 80% of tamoxifen-treated mice develop mucus plugging in multiple nasal cavities

impaired mucociliary clearance ( J:277289 )

• mucociliary clearance is impaired in tamoxifen-treated mice, with impairment of clearance correlated with changes in nasal air space and presence of mucus in the nose

• effective speed of mucociliary clearance is slower and the directionality of the flow is affected in tamoxifen-treated mice with increased nasal air space and mucus accumulation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia		DOID:9562	OMIM:PS244400	J:277289