Phenotypes associated with this allele

• Allele Symbol: Col1a1^{tm3(tetO-Fosl1,-DsRed)Wag}
• Allele Name: targeted mutation 3, Erwin F Wagner
• Allele ID: MGI:5585716
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Col1a1^tm3(tetO-Fosl1,-DsRed)Wag/Col1a1^+ Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/Gt(ROSA)26Sor^+	involves: 129S4/SvJae * C57BL/6	MGI:5586502
cx2	Col1a1^tm3(tetO-Fosl1,-DsRed)Wag/Col1a1^+ Tg(Cebpb-tTA)5Bjd/0	involves: 129S4/SvJae * C57BL/6 * NMRI	MGI:5586503

Genotype
MGI:5586502

cx1

• Allelic Composition: Col1a1^{tm3(tetO-Fosl1,-DsRed)Wag}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver fibrosis ( J:213764 )

• periportal with immune infiltrate in doxycycline-treated mice

skeleton

abnormal skeleton morphology ( J:213764 )

• in doxycycline-treated mice at necropsy

growth/size/body

weight loss ( J:213764 )

• in doxycycline-treated mice

enlarged spleen ( J:213764 )

• in doxycycline-treated mice at necropsy

behavior/neurological

lethargy ( J:213764 )

• in doxycycline-treated mice

homeostasis/metabolism

ascites ( J:213764 )

• sometimes in doxycycline-treated mice at necropsy

hematopoietic system

enlarged spleen ( J:213764 )

• in doxycycline-treated mice at necropsy

immune system

enlarged spleen ( J:213764 )

• in doxycycline-treated mice at necropsy

Genotype
MGI:5586503

cx2

• Allelic Composition: Col1a1^{tm3(tetO-Fosl1,-DsRed)Wag}/Col1a1⁺; Tg(Cebpb-tTA)5Bjd/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

growth/size/body

increased liver weight ( J:213764 )

• in mice exposed to DCC

mortality/aging

mortality/aging ( J:213764 )

N • mice are viable

homeostasis/metabolism

decreased circulating cholesterol level ( J:213764 )

• in mice exposed to DCC

increased circulating cholesterol level ( J:210545 )

• mild in mice fed a high fat diet

increased circulating triglyceride level ( J:210545 )

• mild in mice fed a high fat diet

decreased circulating interleukin-6 level ( J:210545 )

decreased circulating alanine transaminase level ( J:210545 , J:213764 )

• compared with control mice when fed a high fat diet (J:210545)

• reversion of high fat diet-induced elevations in alanine transaminase level following withdrawal of doxycycline (J:210545)

• in mice exposed to DCC (J:213764)

impaired glucose tolerance ( J:210545 )

• slightly worse than in control mice fed a high fat diet

insulin resistance ( J:210545 )

• slightly worse than in control mice when fed a high fat diet

increased bile salt level ( J:213764 )

• relative to body weight in mice exposed to DCC compared with control mice

decreased liver triglyceride level ( J:210545 )

• compared with control mice when fed a high fat diet

• reversion of high fat diet-induced steatosis following withdrawal of doxycycline

• however, adenorival Pparg restores diet-induced steatosis

decreased susceptibility to injury ( J:213764 )

• mice exposed to DCC exhibit reduced liver damage (increased relative liver weight and reduced ALT levels) compared with control mice

• mice subjected to acetaminophen-induced hepatotoxicity exhibit reduced liver damage compared with control mice

liver/biliary system

liver/biliary system phenotype ( J:213764 )

N • mice exhibit no signs of liver fibrosis and serum parameters

liver inflammation ( J:210545 )

• reduced compared with control mice fed a high fat diet

abnormal liver morphology ( J:210545 )

• less pale livers with a reduction in lipid droplets than in control mice when a high fat diet

increased liver weight ( J:213764 )

• in mice exposed to DCC

decreased liver triglyceride level ( J:210545 )

• compared with control mice when fed a high fat diet

• reversion of high fat diet-induced steatosis following withdrawal of doxycycline

• however, adenorival Pparg restores diet-induced steatosis

decreased liver weight ( J:210545 )

• compared with control mice when fed a high fat diet

• in mice fed a high fat diet following withdrawal of doxycycline

decreased susceptibility to diet-induced hepatic steatosis ( J:210545 )

• reduction in lipid droplets compared with control mice when fed a high fat diet

• reversion of high fat diet-induced steatosis following doxycycline treatment

• however, adenorival Pparg restores diet-induced steatosis

immune system

decreased circulating interleukin-6 level ( J:210545 )

liver inflammation ( J:210545 )

• reduced compared with control mice fed a high fat diet