All Phenotypes Gt(ROSA)26Sor<tm1(Sirt1)Ktm> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}/Gt(ROSA)26Sor⁺ Tg(Pomc1-cre)16Lowl/0	involves: 129 * C57BL/6J * FVB/N	MGI:5586724
cn2	Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}/Gt(ROSA)26Sor⁺ Tg(Agrp-cre)1Gsb/0	involves: 129 * C57BL/6J * FVB/N	MGI:5586725

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:209418 )

N	• mice exhibit normal hypothalamus-pituitary-adrenal and hypothalamus-pituitary-thyroid axes

increased adipose tissue noradrenaline turnover ( J:209418 )

• noradrenaline turnover in the white adipose tissue is increased in male mice compared to in control mice

• however, turnover in skeletal muscle is normal

decreased susceptibility to induced hypothermia ( J:209418 )

• mice tend to be cold-resistant for short-term exposure compared with control mice

• however, mice fed a high fat high sugar diet exhibit normal cold resistance

decreased circulating thyroxine level ( J:209418 )

• tend

increased energy expenditure ( J:209418 )

• male mice fed normal chow exhibit increased energy expenditure suggested by a tend toward higher oxygen consumption and lower locomotor activity compared with control mice

• however, mice fed a high fat high sugar diet exhibit normal energy expenditure

increased oxygen consumption ( J:209418 )

• trend in male mice fed normal chow

increased response to leptin ( J:209418 )

• mice exhibit improved leptin sensitivity compared with control mice

growth/size/body

growth/size/body region phenotype ( J:209418 )

N	• male and female mice fed normal chow exhibit normal body length • mice fed a high fat high sugar diet exhibit normal weight gain

decreased susceptibility to age related obesity ( J:209418 )

• in male, but not female, mice fed normal chow

adipose tissue

decreased total body fat amount ( J:209418 )

• in male, but not female, mice fed normal chow

• however, mice fed a high fat high sugar diet exhibit normal adiposity

decreased epididymal fat pad weight ( J:209418 )

• in male mice fed normal chow

increased adipose tissue noradrenaline turnover ( J:209418 )

• noradrenaline turnover in the white adipose tissue is increased in male mice compared to in control mice

• however, turnover in skeletal muscle is normal

behavior/neurological

behavior/neurological phenotype ( J:209418 )

N	• female and male mice exhibit normal food intake

decreased locomotor activity ( J:209418 )

• trend in male mice fed normal chow

• however, mice fed a high fat high sugar diet exhibit normal locomotion

Allelic Composition	Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}/Gt(ROSA)26Sor⁺ Tg(Agrp-cre)1Gsb/0
Genetic Background	involves: 129 * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Sirt1)Ktm} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Agrp-cre)1Gsb mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:209418 )

N	• mice exhibit normal body length • female and male mice fed a high fat high sugar diet exhibit normal body weight

increased body weight ( J:209418 )

• female mice exhibit a tend toward increased body weight

decreased susceptibility to age related obesity ( J:209418 )

• in male mice fed normal chow

behavior/neurological

behavior/neurological phenotype ( J:209418 )

N	• mice fed normal chow or a high fat high sugar diet exhibit normal locomotor activity

decreased food intake ( J:209418 )

• in male mice fed normal chow

increased food intake ( J:209418 )

• in female mice fed normal chow

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:209418 )

N	• mice fed normal chow exhibit normal energy expenditure, plasma T4 levels, fasting-induced lipolysis and rectal temperature • mice fed a high fat high sugar diet exhibit normal energy expenditure and cold tolerance

increased response to leptin ( J:209418 )

• mice exhibit improved leptin sensitivity compared with control mice

adipose tissue

adipose tissue phenotype ( J:209418 )

N	• mice fed normal chow or a high fat high sugar diet exhibit normal adiposity

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