All Phenotypes Gt(ROSA)26Sor<tm2(ITK/Syk)Hjum> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum}/Gt(ROSA)26Sor⁺ Tg(Cd4-cre)1Cwi/0	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:5586735
cn2	Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum}/Gt(ROSA)26Sor⁺ Tg(Lck-cre)I57Jxm/0	involves: 129S6/SvEvTac * ICR	MGI:5586736

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:207306 )

N	• mice exhibit normal percentages and total cell numbers of double positive or single positive thymocytes and CD4+ or CD8+ peripheral T cells in the spleen

increased mature B cell number ( J:207306 )

• in the spleen

increased plasma cell number ( J:207306 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:207306 )

increased activated T cell number ( J:207306 )

• CD4+ and CD8+ T cells in the spleen

abnormal spleen morphology ( J:207306 )

• with altered follicular structure and widely scattered T cells

enlarged spleen ( J:207306 )

• with expanded T cell pool, mainly CD4+ T cells

abnormal immunoglobulin level ( J:207306 )

increased IgA level ( J:207306 )

increased IgG level ( J:207306 )

increased IgM level ( J:207306 )

abnormal circulating cytokine level ( J:207306 )

increased circulating interferon-gamma level ( J:207306 )

increased circulating interleukin-10 level ( J:207306 )

• slightly

increased circulating interleukin-2 level ( J:207306 )

• slightly

increased circulating interleukin-4 level ( J:207306 )

increased circulating interleukin-6 level ( J:207306 )

• slightly

increased circulating tumor necrosis factor level ( J:207306 )

abnormal cytokine secretion ( J:207306 )

increased interferon-gamma secretion ( J:207306 )

• from un-stimulated splenic T cells

increased interleukin-10 secretion ( J:207306 )

• from un-stimulated and stimulated splenic T cells

increased interleukin-2 secretion ( J:207306 )

• from un-stimulated splenic T cells

increased interleukin-4 secretion ( J:207306 )

• from stimulated splenic T cells

increased interleukin-6 secretion ( J:207306 )

• from un-stimulated splenic T cells

increased tumor necrosis factor secretion ( J:207306 )

• from un-stimulated splenic T cells

increased inflammatory response ( J:207306 )

• systemic inflammation

liver/biliary system

abnormal liver morphology ( J:207306 )

homeostasis/metabolism

abnormal circulating cytokine level ( J:207306 )

increased circulating interferon-gamma level ( J:207306 )

increased circulating interleukin-10 level ( J:207306 )

• slightly

increased circulating interleukin-2 level ( J:207306 )

• slightly

increased circulating interleukin-4 level ( J:207306 )

increased circulating interleukin-6 level ( J:207306 )

• slightly

increased circulating tumor necrosis factor level ( J:207306 )

hematopoietic system

increased mature B cell number ( J:207306 )

• in the spleen

increased plasma cell number ( J:207306 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:207306 )

increased activated T cell number ( J:207306 )

• CD4+ and CD8+ T cells in the spleen

abnormal spleen morphology ( J:207306 )

• with altered follicular structure and widely scattered T cells

enlarged spleen ( J:207306 )

• with expanded T cell pool, mainly CD4+ T cells

abnormal immunoglobulin level ( J:207306 )

increased IgA level ( J:207306 )

increased IgG level ( J:207306 )

increased IgM level ( J:207306 )

growth/size/body

enlarged spleen ( J:207306 )

• with expanded T cell pool, mainly CD4+ T cells

Allelic Composition	Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum}/Gt(ROSA)26Sor⁺ Tg(Lck-cre)I57Jxm/0
Genetic Background	involves: 129S6/SvEvTac * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(ITK/Syk)Hjum} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Lck-cre)I57Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:207306 )

N	• mice exhibit normal percentages and total cell numbers of double positive or single positive thymocytes and CD4+ or CD8+ peripheral T cells in the spleen

increased mature B cell number ( J:207306 )

• in the spleen

increased plasma cell number ( J:207306 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:207306 )

increased activated T cell number ( J:207306 )

• CD4+ and CD8+ T cells in the spleen

abnormal spleen morphology ( J:207306 )

• with altered follicular structure and widely scattered T cells

enlarged spleen ( J:207306 )

• with expanded T cell pool, mainly CD4+ T cells

abnormal immunoglobulin level ( J:207306 )

increased IgA level ( J:207306 )

increased IgG level ( J:207306 )

increased IgM level ( J:207306 )

abnormal circulating cytokine level ( J:207306 )

increased circulating interferon-gamma level ( J:207306 )

increased circulating interleukin-10 level ( J:207306 )

• slightly

increased circulating interleukin-2 level ( J:207306 )

• slightly

increased circulating interleukin-4 level ( J:207306 )

increased circulating interleukin-6 level ( J:207306 )

• slightly

increased circulating tumor necrosis factor level ( J:207306 )

abnormal cytokine secretion ( J:207306 )

increased interferon-gamma secretion ( J:207306 )

• from un-stimulated splenic T cells

increased interleukin-10 secretion ( J:207306 )

• from un-stimulated and stimulated splenic T cells

increased interleukin-2 secretion ( J:207306 )

• from un-stimulated splenic T cells

increased interleukin-4 secretion ( J:207306 )

• from stimulated splenic T cells

increased interleukin-6 secretion ( J:207306 )

• from un-stimulated splenic T cells

increased tumor necrosis factor secretion ( J:207306 )

• from un-stimulated splenic T cells

increased inflammatory response ( J:207306 )

• systemic inflammation

liver/biliary system

abnormal liver morphology ( J:207306 )

homeostasis/metabolism

abnormal circulating cytokine level ( J:207306 )

increased circulating interferon-gamma level ( J:207306 )

increased circulating interleukin-10 level ( J:207306 )

• slightly

increased circulating interleukin-2 level ( J:207306 )

• slightly

increased circulating interleukin-4 level ( J:207306 )

increased circulating interleukin-6 level ( J:207306 )

• slightly

increased circulating tumor necrosis factor level ( J:207306 )

hematopoietic system

increased mature B cell number ( J:207306 )

• in the spleen

increased plasma cell number ( J:207306 )

• in the spleen

increased CD4-positive, alpha-beta T cell number ( J:207306 )

increased activated T cell number ( J:207306 )

• CD4+ and CD8+ T cells in the spleen

abnormal spleen morphology ( J:207306 )

• with altered follicular structure and widely scattered T cells

enlarged spleen ( J:207306 )

• with expanded T cell pool, mainly CD4+ T cells

abnormal immunoglobulin level ( J:207306 )

increased IgA level ( J:207306 )

increased IgG level ( J:207306 )

increased IgM level ( J:207306 )

growth/size/body

enlarged spleen ( J:207306 )

• with expanded T cell pool, mainly CD4+ T cells

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