Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm3.1(CAG-SORL1)Tew}
• Allele Name: targeted mutation 3.1, Thomas E Willnow
• Allele ID: MGI:5586989
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^tm3.1(CAG-SORL1)Tew/Gt(ROSA)26Sor^tm3.1(CAG-SORL1)Tew	Not Specified	MGI:5586990
ht2	Gt(ROSA)26Sor^tm3.1(CAG-SORL1)Tew/Gt(ROSA)26Sor^+	Not Specified	MGI:5586991
cx3	Gt(ROSA)26Sor^tm3.1(CAG-SORL1)Tew/Gt(ROSA)26Sor^+ Tg(APPV717F)109Ili/0	Not Specified	MGI:5586992

Genotype
MGI:5586990

hm1

• Allelic Composition: Gt(ROSA)26Sor^{tm3.1(CAG-SORL1)Tew}/Gt(ROSA)26Sor^{tm3.1(CAG-SORL1)Tew}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:213687 )

• fewer (10%) than the expected (25%) numbers of adult homozygotes are seen

perinatal lethality, incomplete penetrance ( J:213687 )

• perinatal lethality is seen in about 50% of newborns

nervous system

abnormal nervous system morphology ( J:213687 )

• newborn and adult mice show reduced concentrations of murine amyloid beta40 and amyloid beta42 peptides

• however, concentration of the soluble APP alpha is not affected

Genotype
MGI:5586991

ht2

• Allelic Composition: Gt(ROSA)26Sor^{tm3.1(CAG-SORL1)Tew}/Gt(ROSA)26Sor⁺
• Genetic Background: Not Specified

nervous system

abnormal nervous system morphology ( J:213687 )

• mice show reduced concentrations of murine amyloid beta40 and amyloid beta42 peptides

• however, concentration of the soluble murine APP alpha is not affected

Genotype
MGI:5586992

cx3

• Allelic Composition: Gt(ROSA)26Sor^{tm3.1(CAG-SORL1)Tew}/Gt(ROSA)26Sor⁺; Tg(APPV717F)109Ili/0
• Genetic Background: Not Specified

nervous system

abnormal nervous system morphology ( J:213687 )

• mice show reduced concentrations of human amyloid beta40 and amyloid beta42 peptides in cortical and hippocampal extracts

• however, basal concentrations of brain interstitial fluid amyloid beta40 are unchanged in the brain parenchyma of adults compared to single Tg(APPV717F)109Ili mice

• concentrations of the soluble human APP alpha and APP beta are not affected