Phenotypes associated with this allele

• Allele Symbol: Ncor1^tm1.1Anh
• Allele Name: targeted mutation 1.1, Anthony N Hollenberg
• Allele ID: MGI:5587819
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncor1^tm1.1Anh/Ncor1^tm1.1Anh	involves: 129S4/SvJae * C57BL/6J	MGI:5587845

Genotype
MGI:5587845

hm1

• Allelic Composition: Ncor1^tm1.1Anh/Ncor1^tm1.1Anh
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:213990 )

N • mice are born in Mendelian ratios

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:213990 )

N • mice exhibit normal thyroid-stimulating hormone levels and body temperature

decreased circulating triiodothyronine level ( J:213990 )

• total in male and female mice

increased energy expenditure ( J:213990 )

increased oxygen consumption ( J:213990 )

abnormal thyroxine level ( J:213990 )

• mice treated with thyroid-stimulating hormone fail to exhibit as much of an increase in T4 as in wild-type mice

decreased circulating thyroxine level ( J:213990 )

• at P10, but not P5

• total and free in male and female mice

abnormal response/metabolism to endogenous compounds ( J:213990 )

• under hypothyroid conditions, mice exhibit increased sensitivity to thyroid hormone (TH) with normalized cholesterol levels and heart rate upon T3 replacement compared with wild-type mice

• however, TH sensitivity at the level of the hypothalamus and the pituitary is normal

cardiovascular system

increased heart weight ( J:213990 )

• under hypothyroid conditions upon T3 replacement

increased heart left ventricle weight ( J:213990 )

• under basal and hypothyroid conditions

decreased heart rate ( J:213990 )

• in basal state

• worsened under hypothyroid conditions

• however, T3 treatment under hypothyroid conditions normalizes heart rate

growth/size/body

increased heart weight ( J:213990 )

• under hypothyroid conditions upon T3 replacement

decreased body weight ( J:213990 )

• slight at 6 weeks

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:213990 )

N • mice exhibit normal thyroid size

decreased activity of thyroid gland ( J:213990 )

• central hypothyroidism

adipose tissue

decreased total body fat amount ( J:213990 )

• tendency

• however, mice exhibit normal brown adipose tissue activation

behavior/neurological

behavior/neurological phenotype ( J:213990 )

N • mice exhibit normal activity levels and food intake