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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ncor1tm1.1Anh
targeted mutation 1.1, Anthony N Hollenberg
MGI:5587819
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ncor1tm1.1Anh/Ncor1tm1.1Anh involves: 129S4/SvJae * C57BL/6J MGI:5587845


Genotype
MGI:5587845
hm1
Allelic
Composition
Ncor1tm1.1Anh/Ncor1tm1.1Anh
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncor1tm1.1Anh mutation (0 available); any Ncor1 mutation (396 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are born in Mendelian ratios

homeostasis/metabolism
N
• mice exhibit normal thyroid-stimulating hormone levels and body temperature
• mice treated with thyroid-stimulating hormone fail to exhibit as much of an increase in T4 as in wild-type mice
• at P10, but not P5
• total and free in male and female mice
• total in male and female mice
• under hypothyroid conditions, mice exhibit increased sensitivity to thyroid hormone (TH) with normalized cholesterol levels and heart rate upon T3 replacement compared with wild-type mice
• however, TH sensitivity at the level of the hypothalamus and the pituitary is normal

cardiovascular system
• under hypothyroid conditions upon T3 replacement
• under basal and hypothyroid conditions
• in basal state
• worsened under hypothyroid conditions
• however, T3 treatment under hypothyroid conditions normalizes heart rate

growth/size/body
• under hypothyroid conditions upon T3 replacement
• slight at 6 weeks

endocrine/exocrine glands
N
• mice exhibit normal thyroid size
• central hypothyroidism

adipose tissue
• tendency
• however, mice exhibit normal brown adipose tissue activation

behavior/neurological
N
• mice exhibit normal activity levels and food intake





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory