mortality/aging
N |
• mice are born in Mendelian ratios
|
homeostasis/metabolism
N |
• mice exhibit normal thyroid-stimulating hormone levels and body temperature
|
• mice treated with thyroid-stimulating hormone fail to exhibit as much of an increase in T4 as in wild-type mice
|
• at P10, but not P5
• total and free in male and female mice
|
• total in male and female mice
|
• under hypothyroid conditions, mice exhibit increased sensitivity to thyroid hormone (TH) with normalized cholesterol levels and heart rate upon T3 replacement compared with wild-type mice
• however, TH sensitivity at the level of the hypothalamus and the pituitary is normal
|
cardiovascular system
• under hypothyroid conditions upon T3 replacement
|
• under basal and hypothyroid conditions
|
• in basal state
• worsened under hypothyroid conditions
• however, T3 treatment under hypothyroid conditions normalizes heart rate
|
growth/size/body
• under hypothyroid conditions upon T3 replacement
|
• slight at 6 weeks
|
endocrine/exocrine glands
N |
• mice exhibit normal thyroid size
|
• central hypothyroidism
|
adipose tissue
• tendency
• however, mice exhibit normal brown adipose tissue activation
|
behavior/neurological
N |
• mice exhibit normal activity levels and food intake
|