About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ncor1tm1.1Anh
targeted mutation 1.1, Anthony N Hollenberg
MGI:5587819
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ncor1tm1.1Anh/Ncor1tm1.1Anh involves: 129S4/SvJae * C57BL/6J MGI:5587845


Genotype
MGI:5587845
hm1
Allelic
Composition
Ncor1tm1.1Anh/Ncor1tm1.1Anh
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncor1tm1.1Anh mutation (0 available); any Ncor1 mutation (396 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are born in Mendelian ratios

homeostasis/metabolism
N
• mice exhibit normal thyroid-stimulating hormone levels and body temperature
• mice treated with thyroid-stimulating hormone fail to exhibit as much of an increase in T4 as in wild-type mice
• at P10, but not P5
• total and free in male and female mice
• total in male and female mice
• under hypothyroid conditions, mice exhibit increased sensitivity to thyroid hormone (TH) with normalized cholesterol levels and heart rate upon T3 replacement compared with wild-type mice
• however, TH sensitivity at the level of the hypothalamus and the pituitary is normal

cardiovascular system
• under hypothyroid conditions upon T3 replacement
• under basal and hypothyroid conditions
• in basal state
• worsened under hypothyroid conditions
• however, T3 treatment under hypothyroid conditions normalizes heart rate

growth/size/body
• under hypothyroid conditions upon T3 replacement
• slight at 6 weeks

endocrine/exocrine glands
N
• mice exhibit normal thyroid size
• central hypothyroidism

adipose tissue
• tendency
• however, mice exhibit normal brown adipose tissue activation

behavior/neurological
N
• mice exhibit normal activity levels and food intake





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory