Phenotypes associated with this allele

• Allele Symbol: Snhg14^tm1Alb
• Allele Name: targeted mutation 1, Arthur L Beaudet
• Allele ID: MGI:5587826
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Snhg14^tm1Alb/Snhg14^+	B6.129S7-Snhg14^tm1Alb	MGI:5587828
cx2	Snhg14^tm1Alb/Snhg14^+ Ube3a^tm1Alb/Ube3a^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:5587829

Genotype
MGI:5587828

ht1

• Allelic Composition: Snhg14^tm1Alb/Snhg14⁺
• Genetic Background: B6.129S7-Snhg14^tm1Alb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:207499 )

N • when this allele is inherited maternally, mice exhibit normal performance on a rotarod, dowel test and hanging wire test

Genotype
MGI:5587829

cx2

• Allelic Composition: Snhg14^tm1Alb/Snhg14⁺; Ube3a^tm1Alb/Ube3a⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:207499 )

N • when the knock-out allele is inherited maternally, mice exhibit fully restored contextual conditioning behavior compared with mice heterozygous for the wild-type allele

abnormal emotion/affect behavior ( J:207499 )

• when the knock-out allele is inherited maternally, mice exhibit a slight improvement in performance in a marble burying test compared with mice heterozygous for the wild-type allele

impaired coordination ( J:207499 )

• on an accelerating rotarod in later trials when the knock-out allele is inherited maternally

• however, performance improved in the first few trials and in the hanging wire and dowel tests

decreased locomotor activity ( J:207499 )

• when the knock-out allele is inherited maternally, mice exhibit a trend towards improved activity levels compared with mice heterozygous for the wild-type allele

growth/size/body

growth/size/body region phenotype ( J:207499 )

N • when the knock-out allele is inherited maternally, mice exhibit normal body weight unlike in mice heterozygous for the wild-type allele

nervous system

nervous system phenotype ( J:207499 )

N • when the knock-out allele is inherited maternally, mice exhibit restored long term potentiation compared with mice heterozygous for the wild-type allele