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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prmt1tm1c(EUCOMM)Wtsi
targeted mutation 1c, Welcome Trust Sanger Institute
MGI:5587827
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Prmt1tm1c(EUCOMM)Wtsi/Prmt1+
Rb1tm3Tyj/Rb1tm3Tyj
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1 MGI:7486124


Genotype
MGI:7486124
cn1
Allelic
Composition		 Prmt1tm1c(EUCOMM)Wtsi/Prmt1+
Rb1tm3Tyj/Rb1tm3Tyj
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt1tm1c(EUCOMM)Wtsi mutation (2 available); any Prmt1 mutation (35 available)
Rb1tm3Tyj mutation (10 available); any Rb1 mutation (111 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (243 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:245660 )
• mice begin to die at ~100 days of age and all die by around 200 days of age, with a median survival similar to that of mutant mice homozygous for the wild-type Prmt1 allele

neoplasm
increased osteosarcoma incidence ( J:245660 )
• microPET/CT imaging suggested an increase in the presence of osteosarcomas at 100 days of age

skeleton
increased osteosarcoma incidence ( J:245660 )
• microPET/CT imaging suggested an increase in the presence of osteosarcomas at 100 days of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory