Phenotypes associated with this allele

• Allele Symbol: Tg(Gpr151-cre)#Ito
• Allele Name: transgene insertion, Shigeyoshi Itohara
• Allele ID: MGI:5587996
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Eno2^tm1(DTA)Hsak/Eno2^+ Tg(Gpr151-cre)#Ito/0	involves: C57BL/6	MGI:5588027

Genotype
MGI:5588027

cn1

• Allelic Composition: Eno2^tm1(DTA)Hsak/Eno2⁺; Tg(Gpr151-cre)#Ito/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:214076 )

N • mice exhibit normal performance in fear conditioning tests and saccharin preference

impaired behavioral response to nicotine ( J:214076 )

• following systemic nicotine administration, mice fail to exhibit slowed down nose-poke reaction and enhanced adaptation unlike control mice

abnormal habituation to a new environment ( J:214076 )

• absence of habituation upon repeated exposure to a new environment

• however, exploration of a new environment is normal

impaired spatial learning ( J:214076 )

• in a corner avoidance test

abnormal spatial working memory ( J:214076 )

• poor spatial memory in a Morris water maze

• tendency to working memory deficits in a radial arm maze

increased anxiety-related response ( J:214076 )

• modest in an open field test (reduced time in center area) and an elevated plus maze (reduced time in open arms)

abnormal impulsive behavior control ( J:214076 )

• premature response in a 5-choice serial reaction time task (5-CSRTT)

• in a T maze, mice exhibit devalued reward by delay and effort compared with control mice

• in a saccharin preference test, mice exhibit poorly controlled response to reward compared with control mice

• however, erroneous nose-pokes are normal indicating unaltered spatial attention

hyperactivity ( J:214076 )

• tendency during the early night period in the home cage

• visit hyperactivity in free, nose-poke and drinking adaptation tests

• however, exploration of a new environment is normal

nervous system

abnormal midbrain morphology ( J:214076 )

• reduced acetylcholine concentration in interpeduncular nucleus

• reduced interpeduncular nucleus volume not due to cell loss

abnormal habenula morphology ( J:214076 )

• mice exhibit reduced number of neurons, specifically substance P-nergic and cholinergic cells, in the habenular complex medial and lateral nuclei compared with control mice

• reduced transverse area of fasciculus retroflux

abnormal cholinergic neuron morphology ( J:214076 )

• mice exhibit reduced number of neurons, specifically substance P-nergic and cholinergic cells, in the habenular complex medial and lateral nuclei compared with control mice

• reduced acetylcholine concentration in interpeduncular nucleus

decreased neuron number ( J:214076 )

• mice exhibit reduced number of neurons, specifically substance P-nergic and cholinergic cells, in the habenular complex medial and lateral nuclei compared with control mice

• however, the number of neurons in the paraventricular and reuniens thalamic nuclei is normal

decreased prepulse inhibition ( J:214076 )