Analysis Tools
immune system
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• 2 out of 3 livers from transgenic mice exhibit a chronic infiltration of inflammatory cells
• infiltrate is found in periportal areas, around big collecting veins and within liver parenchyma
• infiltrate consists of big clusters of leukocytes composed primarily of T cells and macrophages as well as some monocytes, neutrophils, NK cells and granulocytes
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• mice are less susceptible to hepatic injury (hepatitis) than controls, as determined by response to concanavalin A (Con A) administration
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• kidneys from transgenic mice exhibit a chronic infiltration of inflammatory cells
• infiltrate is found around big veins in the cortex and medulla, but not around renal arteries or glomeruli
• infiltrate consists of big clusters of leukocytes composed primarily of T cells and macrophages as well as some monocytes, neutrophils, NK cells and granulocytes
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• 1 out of 3 lungs from transgenic mice exhibit a chronic infiltration of inflammatory cells
• infiltrate is found at vessels of intermediate size and around bronchi
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liver/biliary system
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• 2 out of 3 livers from transgenic mice exhibit a chronic infiltration of inflammatory cells
• infiltrate is found in periportal areas, around big collecting veins and within liver parenchyma
• infiltrate consists of big clusters of leukocytes composed primarily of T cells and macrophages as well as some monocytes, neutrophils, NK cells and granulocytes
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renal/urinary system
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• kidneys from transgenic mice exhibit a chronic infiltration of inflammatory cells
• infiltrate is found around big veins in the cortex and medulla, but not around renal arteries or glomeruli
• infiltrate consists of big clusters of leukocytes composed primarily of T cells and macrophages as well as some monocytes, neutrophils, NK cells and granulocytes
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respiratory system
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• 1 out of 3 lungs from transgenic mice exhibit a chronic infiltration of inflammatory cells
• infiltrate is found at vessels of intermediate size and around bronchi
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