All Phenotypes Hmgn5<tm1.2Mbus> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hmgn5^tm1.2Mbus
targeted mutation 1.2, Michael Bustin
MGI:5588022

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hmgn5^tm1.2Mbus/Hmgn5^tm1.2Mbus	involves: 129S4/SvJae * C57BL/6J	MGI:5588102
ot2	Hmgn5^tm1.2Mbus/Y	involves: 129S4/SvJae * C57BL/6J	MGI:5588107

Allelic Composition	Hmgn5^tm1.2Mbus/Hmgn5^tm1.2Mbus
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgn5^tm1.2Mbus mutation (0 available); any Hmgn5 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

emphysema ( J:199604 )

• emphysema-like phenotype

abnormal respiration ( J:199604 )

• differences in lung volumes (inspiratory capacity, expiratory reserve volume, vital capacity, total lung capacity and forced vital capacity), flow rates and mechanical properties

abnormal inspiratory capacity ( J:199604 )

abnormal forced expiratory flow rates ( J:199604 )

abnormal respiratory mechanics ( J:199604 )

abnormal total lung capacity ( J:199604 )

hematopoietic system

abnormal erythrocyte cell number ( J:199604 )

decreased granulocyte number ( J:199604 )

• lower frequency

increased CD8-positive, alpha-beta T cell number ( J:199604 )

• higher frequency

increased IgA level ( J:199604 )

decreased IgE level ( J:199604 )

homeostasis/metabolism

abnormal glucose tolerance ( J:199604 )

• sex-specific effects on basal glucose level and glucose tolerance

nervous system

decreased prepulse inhibition ( J:199604 )

• lower acoustic startle activity

immune system

decreased granulocyte number ( J:199604 )

• lower frequency

increased CD8-positive, alpha-beta T cell number ( J:199604 )

• higher frequency

increased IgA level ( J:199604 )

decreased IgE level ( J:199604 )

Allelic Composition	Hmgn5^tm1.2Mbus/Y
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgn5^tm1.2Mbus mutation (0 available); any Hmgn5 mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal erythrocyte cell number ( J:199604 )

decreased granulocyte number ( J:199604 )

• lower frequency

increased CD8-positive, alpha-beta T cell number ( J:199604 )

• higher frequency

increased IgA level ( J:199604 )

decreased IgE level ( J:199604 )

homeostasis/metabolism

abnormal glucose tolerance ( J:199604 )

• sex-specific effects on basal glucose level and glucose tolerance

immune system

decreased granulocyte number ( J:199604 )

• lower frequency

increased CD8-positive, alpha-beta T cell number ( J:199604 )

• higher frequency

increased IgA level ( J:199604 )

decreased IgE level ( J:199604 )

nervous system

decreased prepulse inhibition ( J:199604 )

• lower acoustic startle activity

respiratory system

emphysema ( J:199604 )

• emphysema-like phenotype

abnormal respiration ( J:199604 )

• differences in lung volumes (inspiratory capacity, expiratory reserve volume, vital capacity, total lung capacity and forced vital capacity), flow rates and mechanical properties

abnormal inspiratory capacity ( J:199604 )

abnormal forced expiratory flow rates ( J:199604 )

abnormal respiratory mechanics ( J:199604 )

abnormal total lung capacity ( J:199604 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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