Phenotypes associated with this allele

• Allele Symbol: Nrp1^tm1.1Izac
• Allele Name: targeted mutation 1.1, Ian Zachary
• Allele ID: MGI:5588167
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrp1^tm1.1Izac/Nrp1^tm1.1Izac	involves: 129S2/SvPas * C57BL/6	MGI:5588176

Genotype
MGI:5588176

hm1

• Allelic Composition: Nrp1^tm1.1Izac/Nrp1^tm1.1Izac
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:208348 )

• fewer than expected mice are present after 8 weeks

postnatal lethality, incomplete penetrance ( J:208348 )

• although born in Mendelian ratios, fewer than expected mice survive to P21

cardiovascular system

abnormal brain vasculature morphology ( J:208348 )

• fewer blood vessel branching in the subventricular vascular plexus at E12.

• however, the number of radial vessels in the hindbrain is normal

abnormal retina vasculature morphology ( J:208348 )

• at P7, mice exhibit reduced extension of primary vascular plexus toward the retinal margin with a reduction in arteries and veins compared with wild-type mice

• delayed formation of deep and intermediate vascular plexi at P21 indicated by reduced vascular density

abnormal retina blood vessel morphology ( J:208348 )

• fewer arteries and veins than in wild-type mice

• reduced vessel coverage by vascular smooth muscle cells in the retina at P7 and P21

abnormal induced retina neovascularization ( J:208348 )

• reduced angiogenesis with oxygen-induced retinopathy

decreased angiogenesis ( J:208348 )

• mild effect on vessel density in the head and trunk at E9.5

• defective retinal angiogenesis and arteriogenesis

• fewer blood vessel branching in the subventricular vascular plexus at E12.5

• reduced VEGF-induced angiogenesis

• however, mice exhibit normal pharyngeal arch arteries and intersomitic vessels and delayed retinal angiogenesis is recovered by P21

vascular smooth muscle hypoplasia ( J:208348 )

• reduced vessel coverage by vascular smooth muscle cells in the retina at P7 and P21

abnormal coronary vessel morphology ( J:208348 )

• fewer coronary arteries and capillaries

• capillaries are abnormal and sparse, especially in the subendomyocardium

abnormal coronary artery morphology ( J:208348 )

• fewer coronary arteries

growth/size/body

decreased body size ( J:208348 )

• at P7 and between 6 and 18 weeks

neoplasm

decreased tumor growth/size ( J:208348 )

• failure B16-F1 murine melanoma growth when transplanted into mice

vision/eye

abnormal retina vasculature morphology ( J:208348 )

• at P7, mice exhibit reduced extension of primary vascular plexus toward the retinal margin with a reduction in arteries and veins compared with wild-type mice

• delayed formation of deep and intermediate vascular plexi at P21 indicated by reduced vascular density

abnormal retina blood vessel morphology ( J:208348 )

• fewer arteries and veins than in wild-type mice

• reduced vessel coverage by vascular smooth muscle cells in the retina at P7 and P21

abnormal induced retina neovascularization ( J:208348 )

• reduced angiogenesis with oxygen-induced retinopathy

muscle

vascular smooth muscle hypoplasia ( J:208348 )

• reduced vessel coverage by vascular smooth muscle cells in the retina at P7 and P21

nervous system

abnormal brain vasculature morphology ( J:208348 )

• fewer blood vessel branching in the subventricular vascular plexus at E12.

• however, the number of radial vessels in the hindbrain is normal