Phenotypes associated with this allele

• Allele Symbol: Ido2^tm1.2Gcp
• Allele Name: targeted mutation 1.2, George C Prendergast
• Allele ID: MGI:5588193
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ido2^tm1.2Gcp/Ido2^tm1.2Gcp	involves: C57BL/6J * FVB/N	MGI:5588326

Genotype
MGI:5588326

hm1

• Allelic Composition: Ido2^tm1.2Gcp/Ido2^tm1.2Gcp
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal regulatory T cell physiology ( J:211949 )

• regulatory T cells from CpG-treated mice fail to suppress ex vivo proliferation of A1 T cells and addition of PD1/PDL1 blocking antibodies fail to enhance A1 proliferation compared with wild-type cells

decreased susceptibility to type IV hypersensitivity reaction ( J:211949 )

• reduced ear swelling, vascular leakiness and cytokine production (IL6, IFN-gamma and TNF) in a contact hypersensitivityreduced ear swelling, vascular leakiness and cytokine production (IL6, IFN-gamma and TNF) in a contact hypersensitivity assay with oxazolone assay with oxazolone

• however, swelling induced with a non-specific irritant (lactic acid) is normal

abnormal chemokine secretion ( J:211949 )

• attenuated chemotactic cytokine production in a contact hypersensitivity assay with oxazolone

• however, lymph node cells treated with PMA and ionomycin exhibit normal secretion

decreased interferon-gamma secretion ( J:211949 )

• in a contact hypersensitivity assay with oxazolone

• however, lymph node cells treated with PMA and ionomycin exhibit normal secretion

decreased interleukin-6 secretion ( J:211949 )

• in a contact hypersensitivity assay with oxazolone

• however, lymph node cells treated with PMA and ionomycin exhibit normal secretion

decreased tumor necrosis factor secretion ( J:211949 )

• in a contact hypersensitivity assay with oxazolone

• however, lymph node cells treated with PMA and ionomycin exhibit normal secretion

neoplasm

neoplasm ( J:211949 )

N • mice exhibit normal inflammatory carcinogenesis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:211949 )

N • mice exhibit normal basal serum kynurenine levels

hematopoietic system

hematopoietic system phenotype ( J:211949 )

N • mice exhibit normal hematopoiesis

abnormal regulatory T cell physiology ( J:211949 )

• regulatory T cells from CpG-treated mice fail to suppress ex vivo proliferation of A1 T cells and addition of PD1/PDL1 blocking antibodies fail to enhance A1 proliferation compared with wild-type cells