Phenotypes associated with this allele

• Allele Symbol: Npy6r^tm1Hhzg
• Allele Name: targeted mutation 1, H Herzog
• Allele ID: MGI:5588329
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npy6r^tm1Hhzg/Npy6r^tm1Hhzg	involves: 129S/SvEvBrd * C57BL/6	MGI:5588350

Genotype
MGI:5588350

hm1

• Allelic Composition: Npy6r^tm1Hhzg/Npy6r^tm1Hhzg
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:210546 )

N • mice exhibit normal fertility

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:210546 )

N • at 15 weeks, mice exhibit normoglycemia in mice fed normal chow

N • after 12 weeks, mice fed a high fat diet are normoglycemic

N • mice exhibit normal serum testosterone levels

increased circulating glucose level ( J:210546 )

• during a glucose tolerance test in mice fed a high fat diet

abnormal circulating corticosterone level ( J:210546 )

• corticosterone rhythm is blunted at intervals of 6 hr or under fasted condition

decreased circulating insulin level ( J:210546 )

• at 15 weeks under nonfasted condition in mice fed normal chow

increased circulating insulin level ( J:210546 )

• in nonfasted mice fed a high fat diet

• during a glucose tolerance test in mice fed a high fat diet

abnormal circulating insulin-like growth factor I level ( J:210546 )

• pancreatic polypeptide (PPY)-treated mice fail to exhibit an increase in serum IGF1 levels unlike in wild-type mice

decreased circulating insulin-like growth factor I level ( J:210546 )

• in fasted mice fed normal chow

abnormal energy expenditure ( J:210546 )

• pancreatic polypeptide (PPY)-treated mice fail to exhibit an increase in energy expenditure unlike wild-type mice

increased susceptibility to diet-induced obesity ( J:210546 )

• in mice fed a high fat diet

increased energy expenditure ( J:210546 )

• at 14 weeks with increased activity in mice fed normal chow

• at 23 weeks with increased resting energy expenditure in mice fed normal chow

• adjusted to lean body mass after 14 weeks in mice fed a high fat diet, more pronounced than in mice fed normal chow

• however, resting energy expenditure in mice fed normal chow is normal

• however, mice fed a high fat diet exhibit normal respiratory exchange ratio

decreased respiratory quotient ( J:210546 )

• at 23 weeks in mice fed normal chow

increased respiratory quotient ( J:210546 )

• at 14 weeks in mice fed normal chow

impaired glucose tolerance ( J:210546 )

• during a glucose tolerance test, mice fed a high fat diet exhibit increased circulating glucose and insulin levels

improved glucose tolerance ( J:210546 )

• at 15 weeks without deterioration at 24 weeks in mice fed normal chow

growth/size/body

decreased lean body mass ( J:210546 )

• at 9, 15, 20 and 24 weeks in mice fed normal chow

• in mice fed a high fat diet

increased susceptibility to age related obesity ( J:210546 )

• late-onset obesity by 24 weeks in mice fed normal chow

increased susceptibility to diet-induced obesity ( J:210546 )

• in mice fed a high fat diet

decreased body size ( J:210546 )

• initially in mice fed a high fat diet

• at 15 weeks in mice fed normal chow

decreased body weight ( J:210546 )

• from 6 to 23 weeks in mice fed normal chow

• however, body weight is normal at 24 weeks

increased liver weight ( J:210546 )

• at 15 weeks in mice fed normal chow

adipose tissue

decreased brown adipose tissue amount ( J:210546 )

• at 15 weeks in mice fed normal chow

increased brown adipose tissue amount ( J:210546 )

• after 16 weeks in mice fed a high fat diet

• at 24 weeks in mice fed normal chow

increased white adipose tissue amount ( J:210546 )

• after 16 weeks in mice fed a high fat diet

• at 24 weeks in mice fed normal chow

decreased total body fat amount ( J:210546 )

• at 15, but not 20 or 24, weeks in mice fed normal chow

increased total body fat amount ( J:210546 )

• at 7 and 14 weeks in mice fed a high fat diet

abnormal abdominal fat pad morphology ( J:210546 )

decreased epididymal fat pad weight ( J:210546 )

• at 15 weeks in mice fed normal chow

increased epididymal fat pad weight ( J:210546 )

• at 24 weeks in mice fed normal chow

decreased inguinal fat pad weight ( J:210546 )

• at 15 weeks in mice fed normal chow

increased inguinal fat pad weight ( J:210546 )

• at 24 weeks in mice fed normal chow

decreased mesenteric fat pad weight ( J:210546 )

• at 15 weeks in mice fed normal chow

decreased retroperitoneal fat pad weight ( J:210546 )

• at 15 weeks in mice fed normal chow

increased retroperitoneal fat pad weight ( J:210546 )

• at 24 weeks in mice fed normal chow

behavior/neurological

abnormal food intake ( J:210546 )

• pancreatic polypeptide (PPY)-treated mice fail to exhibit a reduction in food intake unlike wild-type mice

decreased food intake ( J:210546 )

• in older mice after a 24 hour fast fed a high fat diet

• however, mice fasted for 24 hr and fed a high fat diet exhibit normal food intake

increased food intake ( J:210546 )

• trend at 24 weeks in mice fed normal chow

• after 13 weeks in mice fed a high fat diet

• transient increase in nonfasted mice at 3 weeks when fed a high fat diet

hyperactivity ( J:210546 )

• at 14 weeks in mice fed normal chow

• at 23 weeks during the light phase in mice fed normal chow

• however, mice fed a high fat diet exhibit normal activity

digestive/alimentary system

decreased defecation amount ( J:210546 )

• reduced fecal output after 10 weeks in mice fed a high fat diet and in older mice after a 24 hour fast fed a high fat diet

increased defecation amount ( J:210546 )

• greater fecal output at 15, but not 24, weeks in mice fed normal chow

liver/biliary system

increased liver weight ( J:210546 )

• at 15 weeks in mice fed normal chow

hepatic steatosis ( J:210546 )

• at 15 and 24 weeks in mice fed normal chow