Phenotypes associated with this allele

• Allele Symbol: Ntrk1^tm2.1Tes
• Allele Name: targeted mutation 2.1, Lino Tessarollo
• Allele ID: MGI:5588369
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk1^tm2.1Tes/Ntrk1^tm2.1Tes	B6.129S1(Cg)-Ntrk1^tm2.1Tes	MGI:5588371

Genotype
MGI:5588371

hm1

• Allelic Composition: Ntrk1^tm2.1Tes/Ntrk1^tm2.1Tes
• Genetic Background: B6.129S1(Cg)-Ntrk1^tm2.1Tes

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:209600 )

N • normal neuron composition of the L4 dorsal root ganglion in both new borns and adults

abnormal neuron physiology ( J:209600 )

• more robust response to nerve growth factor (NGF) by E13.5 dorsal root ganglion neurons in culture

behavior/neurological

abnormal thermosensation ( J:209600 )

♂ • more time spent on a 32C plate than controls as opposed to plates that were at a much higher or much lower temperature

abnormal nociception after inflammation ( J:209600 )

♂ • higher spontaneous pain behavior after injection of dilute formalin in the plantar surface of the paw but only during the sensitization and inflammation period

decreased thermal nociceptive threshold ( J:209600 )

♂ • significantly lower withdrawal latency to noxious thermal stimuli