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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zc3h12dtm1Tom
targeted mutation 1, Toshimitsu Matsui
MGI:5588370
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zc3h12dtm1Tom/Zc3h12dtm1Tom B6.Cg-Zc3h12dtm1Tom MGI:5588373


Genotype
MGI:5588373
hm1
Allelic
Composition
Zc3h12dtm1Tom/Zc3h12dtm1Tom
Genetic
Background
B6.Cg-Zc3h12dtm1Tom
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zc3h12dtm1Tom mutation (1 available); any Zc3h12d mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal steady-state lymphopoiesis
• under Th17 cell-skewing conditions, cultured splenic CD4+ T cells exhibit normal differentiation
• stimulated by anti-CD3 antibodies with or without anti-CD28 antibodies
• slightly higher proportion of IL17a-producing CD4+ T cells at peak disease and significantly increased during resolution phase in MOG-treated mice
• from LPS-stimulated B cells
• from LPS-stimulated B cells
• MOG-treated mice exhibit high score and slightly higher proportion of IL17a-producing CD4+ T cells at peak disease and significantly higher proportion of Th17 cells in the CNS during the resolution phase compared with wild-type mice
• however, onset of paralysis and population of IFN-gamma-producing CD4+ Th1 cells are normal

hematopoietic system
• stimulated by anti-CD3 antibodies with or without anti-CD28 antibodies
• slightly higher proportion of IL17a-producing CD4+ T cells at peak disease and significantly increased during resolution phase in MOG-treated mice

cellular
• stimulated by anti-CD3 antibodies with or without anti-CD28 antibodies





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory