immune system
N |
• mice exhibit normal steady-state lymphopoiesis
• under Th17 cell-skewing conditions, cultured splenic CD4+ T cells exhibit normal differentiation
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• stimulated by anti-CD3 antibodies with or without anti-CD28 antibodies
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• slightly higher proportion of IL17a-producing CD4+ T cells at peak disease and significantly increased during resolution phase in MOG-treated mice
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• from LPS-stimulated B cells
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• from LPS-stimulated B cells
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• MOG-treated mice exhibit high score and slightly higher proportion of IL17a-producing CD4+ T cells at peak disease and significantly higher proportion of Th17 cells in the CNS during the resolution phase compared with wild-type mice
• however, onset of paralysis and population of IFN-gamma-producing CD4+ Th1 cells are normal
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hematopoietic system
• stimulated by anti-CD3 antibodies with or without anti-CD28 antibodies
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• slightly higher proportion of IL17a-producing CD4+ T cells at peak disease and significantly increased during resolution phase in MOG-treated mice
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cellular
• stimulated by anti-CD3 antibodies with or without anti-CD28 antibodies
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