Analysis Tools
mortality/aging
| N |
• mice show normal survival
|
growth/size/body
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• pups show a reduced body weight at day 14 which becomes significant at 3 weeks for females and at 2 weeks for males
• body weights are 10-26% reduced within the 11-week observation period
|
homeostasis/metabolism
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• transepidermal water loss is marginally increased relative to wild-type mice
• however, mice show normal stratum corneaum and epidermis
|
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• wound healing is delayed by 26%, however complete restoration of epidermal covering is seen
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integument
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• transepidermal water loss is marginally increased relative to wild-type mice
• however, mice show normal stratum corneaum and epidermis
|
sparse hair
(
J:214122
)
|
• in 14% of newly weaned mutants, the coat is thinner and sparser and this coat phenotype persists throughout the 11-week observation period in about 5% of mutants
• however, in the rest 86% of newly weaned mutants, the coat is indistinguishable from wild-type
• however, the time of pelage hair eruption and hair follicle density and diameter are normal
|
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• mice are born either without whiskers or with shorter, kinky, and curly whiskers and whiskers remain abnormal
|
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• in some mice
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• in some mice
|
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• mice are born either without whiskers or with shorter, kinky, and curly whiskers and whiskers remain abnormal
|
