Phenotypes associated with this allele

• Allele Symbol: Uts2^tm1Ags
• Allele Name: targeted mutation 1, Adel Giaid Schwertani
• Allele ID: MGI:5588699
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uts2^tm1Ags/Uts2^tm1Ags	B6.129P2-Uts2^tm1Ags	MGI:5588704

Genotype
MGI:5588704

hm1

• Allelic Composition: Uts2^tm1Ags/Uts2^tm1Ags
• Genetic Background: B6.129P2-Uts2^tm1Ags

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:214289 )

• macrophages from mutant mice generate more than two times the amount of de novo endogenously synthesized cholesterol as compared to macrophages from control mice, and of this more than two times the relative amount is esterified into cholesteryl ester

• hepatocytes from control mice generate more than ten times the amount of de novo endogenously synthesized cholesterol as compared to hepatocytes from mutant mice, and of this more than two times the relative amount is esterified into cholesteryl ester

• macrophages exhibit increased LDL uptake in the short term (1-4 hours) as compared to wild-type

increased circulating HDL cholesterol level ( J:214289 )

• mice fed hypercholesterolemic diet exhibit more HDL sized lipoproteins of a larger size than do controls

decreased circulating LDL cholesterol level ( J:214289 )

• mice fed hypercholesterolemic diet exhibit less LDL cholesterol than controls

• size and relative amount of LDL is reduced

abnormal apolipoprotein level ( J:214289 )

• hepatocytes secrete less apolipoprotein B in culture than hepatocytes from control mice

abnormal enzyme/coenzyme activity ( J:214289 )

• specific ACAT (acetyl-coenzyme A acetyltransferase) activity is elevated under cholesterol loading conditions in macrophages

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:214289 )

• mice fed high fat diet do not develop hepatic steatosis; steatosis is extensive in control livers