Phenotypes associated with this allele

• Allele Symbol: Akap6^tm1.1Mskf
• Allele Name: targeted mutation 1.1, Michael S Kapiloff
• Allele ID: MGI:5588705
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Akap6^tm1.1Mskf/Akap6^tm1.1Mskf Nkx2-5^tm1(cre)Rjs/0	involves: 129S7/SvEvBrd * C57BL/6 * SJL	MGI:5603566
cn2	Akap6^tm1.1Mskf/Akap6^tm1.1Mskf A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+	involves: C57BL/6 * FVB/N * SJL	MGI:5603568

Genotype
MGI:5603566

cn1

• Allelic Composition: Akap6^tm1.1Mskf/Akap6^tm1.1Mskf; Nkx2-5^tm1(cre)Rjs/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:214288 )

• no overt phenotype is observed by 6 months of age

Genotype
MGI:5603568

cn2

• Allelic Composition: Akap6^tm1.1Mskf/Akap6^tm1.1Mskf; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

cardiovascular system

increased myocardial fiber size ( J:214288 )

• following 2 weeks of TAC or isoproterenol infusion, left venticle (LV) myocytes from mice administered tamoxifen exhibit an increase in cross section area, but to a much lessor extent than controls subjected to the same regime

heart left ventricle hypertrophy ( J:214288 )

• following a long term (LT) TAC, mice administered tamoxifen die as a result of congenital heart failure, but exhibit greater survival than controls subjected to the same regime (6% vs 29%) and do not exhibit pulmonary edema

increased heart left atrium weight ( J:214288 )

• following cardiac stress by long term transverse aortic constriction (LT-TAC), mice administered tamoxifen exhibit increased left atrial weight (35%) as compared controls undergoing a sham procedure, but less than the increase (50%) in controls subjected to the same regime

increased heart left ventricle weight ( J:214288 )

• following a LT-TAC, mice administered tamoxifen die as a result of congenital heart failure, but exhibit greater survival than controls subjected to the same regime (6% vs 29%) and do not exhibit pulmonary edema

increased heart left ventricle wall thickness ( J:214288 )

• following 2 weeks of TAC or isoproterenol infusion, mice administered tamoxifen exhibit increased left ventricular (LV) wall thickness, but to a much lessor extent than controls subjected to the same regime

abnormal heart ventricles weight ( J:214288 )

• following 2 weeks of cardiac stress by transverse aortic constriction (TAC) or isoproterenol infusion, mice administered tamoxifen exhibit increased biventricular weight, but to a much lessor extent than controls subjected to the same regime

• following a 5 week swimming regime, mice administered tamoxifen exhibit an increase in biventricular weight gain, but to a lessor extent than controls subjected to the same regime (13% vs 5%)

cardiac interstitial fibrosis ( J:214288 )

• following a long term LT-TAC, mice administered tamoxifen exhibit increased collagen deposistion, but 78% less collagen deposition as compared controls subjected to the same regime

decreased heart rate ( J:214288 )

• following a 5 week swimming regime, mice administered tamoxifen exhibit lower heart rate than controls subjected to the same regime

growth/size/body

heart left ventricle hypertrophy ( J:214288 )

• following a long term (LT) TAC, mice administered tamoxifen die as a result of congenital heart failure, but exhibit greater survival than controls subjected to the same regime (6% vs 29%) and do not exhibit pulmonary edema

cellular

cardiac interstitial fibrosis ( J:214288 )

• following a long term LT-TAC, mice administered tamoxifen exhibit increased collagen deposistion, but 78% less collagen deposition as compared controls subjected to the same regime

increased cardiomyocyte apoptosis ( J:214288 )

• following a long term LT-TAC, mice administered tamoxifen exhibit increased apoptosis, but 75% less myocardial apoptosis as compared controls subjected to the same regime

muscle

increased myocardial fiber size ( J:214288 )

• following 2 weeks of TAC or isoproterenol infusion, left venticle (LV) myocytes from mice administered tamoxifen exhibit an increase in cross section area, but to a much lessor extent than controls subjected to the same regime

heart left ventricle hypertrophy ( J:214288 )

• following a long term (LT) TAC, mice administered tamoxifen die as a result of congenital heart failure, but exhibit greater survival than controls subjected to the same regime (6% vs 29%) and do not exhibit pulmonary edema

increased cardiomyocyte apoptosis ( J:214288 )

• following a long term LT-TAC, mice administered tamoxifen exhibit increased apoptosis, but 75% less myocardial apoptosis as compared controls subjected to the same regime