Phenotypes associated with this allele

• Allele Symbol: Adamts9^tm1.2Apte
• Allele Name: targeted mutation 1.2, Suneel Apte
• Allele ID: MGI:5603304
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts9^tm1.2Apte/Adamts9^tm1.2Apte	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603307
hm2	Adamts9^tm1.2Apte/Adamts9^tm1.2Apte	involves: C57BL/6J * C57BL/6NTac	MGI:5812911
ht3	Adamts9^tm1.2Apte/Adamts9^+	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603306
ht4	Adamts9^tm1Dgen/Adamts9^tm1.2Apte	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	MGI:5603308
cn5	Adamts9^tm1.1Apte/Adamts9^tm1.2Apte Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603310
cx6	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1.2Apte/Adamts9^+	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603312
cx7	Adamts9^tm1.2Apte/Adamts9^+ B3glct^tm1.2Nari/B3glct^tm1.2Nari	involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6NTac * DBA/2 * SJL	MGI:6407447

Genotype
MGI:5603307

hm1

• Allelic Composition: Adamts9^tm1.2Apte/Adamts9^tm1.2Apte
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:213412 )

• embryos are small and malformed by E7.5

Genotype
MGI:5812911

hm2

• Allelic Composition: Adamts9^tm1.2Apte/Adamts9^tm1.2Apte
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

embryo

abnormal gastrulation ( J:234992 )

abnormal embryo morphology ( J:234992 )

• embryos appear compressed

• embryos appear constricted proximal to the epiblast

abnormal embryonic epiblast morphology ( J:234992 )

• in some E7.5 embryos the epiblast is separated from the extraembryonic ectoderm by the parietal endoderm layer

absent mesoderm ( J:234992 )

• E7.5 embryos lack mesoderm

disorganized embryonic tissue ( J:234992 )

disorganized extraembryonic tissue ( J:234992 )

abnormal visceral endoderm morphology ( J:234992 )

• visceral endoderm is highly folded and lacks apical vacuoles

Genotype
MGI:5603306

ht3

• Allelic Composition: Adamts9^tm1.2Apte/Adamts9⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

cardiovascular system

abnormal heart valve morphology ( J:213412 )

• cardiac valve abnormalities

limbs/digits/tail

limbs/digits/tail phenotype ( J:213412 )

N • soft tissue syndactly is not observed

vision/eye

abnormal eye morphology ( J:213412 )

• eye defects

Genotype
MGI:5603308

ht4

• Allelic Composition: Adamts9^tm1Dgen/Adamts9^tm1.2Apte
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:213412 )

• no viable embryos are identified at E9.5

Genotype
MGI:5603310

cn5

• Allelic Composition: Adamts9^tm1.1Apte/Adamts9^tm1.2Apte; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

limbs/digits/tail

syndactyly ( J:213412 )

• present in all forelimbs and all hindlimbs

• mice do not have structural anomalies of bone or patterning anomalies

interdigital webbing ( J:213412 )

• webs are present in all interdigits, although webs do not extend to the tips of digits

Genotype
MGI:5603312

cx6

• Allelic Composition: Adamts20^bt-Bei1/Adamts20^bt-Bei1; Adamts9^tm1.2Apte/Adamts9⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

craniofacial

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

digestive/alimentary system

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

embryo

abnormal melanoblast morphology ( J:213412 )

• reduced numbers of melanoblasts in hair follicles

growth/size/body

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

integument

abnormal hair follicle melanin granule morphology ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

absent hair follicle melanin granules ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

limbs/digits/tail

syndactyly ( J:213412 )

• soft tissue syndactly

nervous system

abnormal melanoblast morphology ( J:213412 )

• reduced numbers of melanoblasts in hair follicles

pigmentation

abnormal hair follicle melanin granule morphology ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

absent hair follicle melanin granules ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

Genotype
MGI:6407447

cx7

• Allelic Composition: Adamts9^tm1.2Apte/Adamts9⁺; B3glct^tm1.2Nari/B3glct^tm1.2Nari
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6NTac * DBA/2 * SJL

mortality/aging

neonatal lethality, complete penetrance ( J:286130 )

craniofacial

cleft palate ( J:286130 )

• 100% penetrance of cleft palate

digestive/alimentary system

cleft palate ( J:286130 )

• 100% penetrance of cleft palate

growth/size/body

cleft palate ( J:286130 )

• 100% penetrance of cleft palate

vision/eye

abnormal eye morphology ( J:286130 )

• late gestation embryos show eye abnormalities ranging from small eye and/or pupil to absent pupil and/or eye

microphthalmia ( J:286130 )

• small eyes in some mutants

anophthalmia ( J:286130 )

• eyes are absent is some mutants