Analysis Tools|
Allele Symbol Allele Name Allele ID |
Drd1tm2.1Stl targeted mutation 2.1, Susumu Tonegawa MGI:5603761 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit deficits in contextual fear conditioning
• mice exhibit reduced freezing levels in 24 hour fear memory test, however, conditioning to tone is normal in an amygdala-dependent cued-fear conditioning protocol
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• impaired late phase long term potentiation (L-LTP) at the medial perforant path-dentate gyrus synapse
• mice exhibit a reduced fEPSP (excitatory postsynaptic potential) slope following a theta burst used to induce L-LTP as compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit deficits in contextual fear conditioning
• mice exhibit impaired fear memory in 24 hour contextual memory test at multiple time points as compared to control, however, mice exhibit normal cued fear conditioning during tone presentation and have a normal short term memory fear response
• mice exhibit similar fear response between two similar but different contexts, in contrast, controls freeze more in the original (shock) context than in the similar context
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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