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Allele Symbol Allele Name Allele ID |
Drd5tm1.1Stl targeted mutation 1.1, Susumu Tonegawa MGI:5603762 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit deficits in contextual fear conditioning
• mice exhibit reduced freezing levels in 24 hour fear memory test, however, conditioning to tone is normal in an amygdala-dependent cued-fear conditioning protocol
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• impaired late phase long term potentiation (L-LTP) at the medial perforant path-dentate gyrus synapse
• mice exhibit a reduced fEPSP (excitatory postsynaptic potential) slope following a theta burst used to induce L-LTP as compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal contextual fear memory, in contrast to mice carrying the Drd1atm2.1 allele
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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