Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(Tbx1)Rche}
• Allele Name: targeted mutation 1, Ellen R Richie
• Allele ID: MGI:5604017
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxn1^tm3(cre)Nrm/Foxn1^+ Gt(ROSA)26Sor^tm1(Tbx1)Rche/Gt(ROSA)26Sor^+	involves: C57BL/6 * C57BL/6NHsd	MGI:5604018

Genotype
MGI:5604018

cn1

• Allelic Composition: Foxn1^tm3(cre)Nrm/Foxn1⁺; Gt(ROSA)26Sor^{tm1(Tbx1)Rche}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: C57BL/6 * C57BL/6NHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal third pharyngeal pouch morphology ( J:214094 )

• proliferation in the GCM2-negative thymus-fated domain of the 3rd pharyngeal pouch is reduced at E11.5

endocrine/exocrine glands

abnormal thymus development ( J:214094 )

• marker analysis at E15.5 indicates an early block in thymic epithelial cell differentiation, with impaired differentiation of both cortical thymic epithelial cell and medullary thymic epithelial cell lineages and an accumulation of early thymic epithelial cell progenitors

• thymocytes show a partial block at the DN3 to DN4 transition at E15.5 indicating a partial differentiation arrest at the DN3 stage

abnormal thymus epithelium morphology ( J:214094 )

• accumulation of early thymic epithelial cell progenitors

thymus hypoplasia ( J:214094 )

• fetal thymi are severely hypoplastic throughout development and remain so in the postnatal period

decreased thymocyte number ( J:214094 )

• total thymocyte cellularity is decreased by about 5-fold in E15.5 thymi

hematopoietic system

abnormal thymus development ( J:214094 )

• marker analysis at E15.5 indicates an early block in thymic epithelial cell differentiation, with impaired differentiation of both cortical thymic epithelial cell and medullary thymic epithelial cell lineages and an accumulation of early thymic epithelial cell progenitors

• thymocytes show a partial block at the DN3 to DN4 transition at E15.5 indicating a partial differentiation arrest at the DN3 stage

abnormal thymus epithelium morphology ( J:214094 )

• accumulation of early thymic epithelial cell progenitors

thymus hypoplasia ( J:214094 )

• fetal thymi are severely hypoplastic throughout development and remain so in the postnatal period

decreased thymocyte number ( J:214094 )

• total thymocyte cellularity is decreased by about 5-fold in E15.5 thymi

immune system

abnormal thymus development ( J:214094 )

• marker analysis at E15.5 indicates an early block in thymic epithelial cell differentiation, with impaired differentiation of both cortical thymic epithelial cell and medullary thymic epithelial cell lineages and an accumulation of early thymic epithelial cell progenitors

• thymocytes show a partial block at the DN3 to DN4 transition at E15.5 indicating a partial differentiation arrest at the DN3 stage

abnormal thymus epithelium morphology ( J:214094 )

• accumulation of early thymic epithelial cell progenitors

thymus hypoplasia ( J:214094 )

• fetal thymi are severely hypoplastic throughout development and remain so in the postnatal period

decreased thymocyte number ( J:214094 )

• total thymocyte cellularity is decreased by about 5-fold in E15.5 thymi