Phenotypes associated with this allele

• Allele Symbol: Tg(ICAM1)4Grom
• Allele Name: transgene insertion 4, Matthias Gromeier
• Allele ID: MGI:5604232
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(ICAM1)4Grom/?	involves: BALB/cAnNTac	MGI:5604243

Genotype
MGI:5604243

tg1

• Allelic Composition: Tg(ICAM1)4Grom/?
• Genetic Background: involves: BALB/cAnNTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

motor neuron degeneration ( J:92607 )

• motor neurons loss and concurrent microglial infiltration in the lumbar spinal anterior horn is induced in transgenic mice by intramuscular (IM) infection with Coxsackievirus A21 (CAV21)

• motor neuron loss is not observed in dorsal horn, thoracic and cervical spinal cord, brainstem or brain

• spinal cord damage is concentrated in the anterior horn gray matter ipsilateral to injection site

behavior/neurological

abnormal gait ( J:92607 )

• 3-4 days following IM infection with CAV21 transgenic mice develop abnormal gait; symptoms peak on day 7 and some animals recover function

paralysis ( J:92607 )

• 3-4 days following IM infection with CAV21 transgenic mice develop flaccid paralysis (drop-foot) of the injected limb; symptoms peak on day 7 and some animals recover function

paresis ( J:92607 )

• 3-4 days following IM infection with CAV21 transgenic mice develop paresis of the injected limb; symptoms peak on day 7 and some animals recover function

immune system

increased susceptibility to Picornaviridae infection ( J:92607 )

• viral titer is elevated in the spinal tissue of transgenic animals, but is negligible in controls following IM infection of CAV21

• poliomyelitis is induced by CAV21in transgenic mice, but is not observed in controls