Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ticam2M1Btlr mutation 1, Bruce Beutler MGI:5604364 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice with this mutation exhibit diminished secretion of tumor necrosis factor alpha (TNFalpha) in response to the Toll-like receptor 4 (TLR4) ligand, lipopolysaccharide (LPS); TNFalpha secretion by heterozygous mutant mice is intermediate between that of homozygous mutant and wild-type control mice.
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice with this mutation exhibit diminished secretion of tumor necrosis factor alpha (TNFalpha) in response to the Toll-like receptor 4 (TLR4) ligand, lipopolysaccharide (LPS); TNFalpha secretion by heterozygous mutant mice is intermediate between that of homozygous mutant and wild-type control mice.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/22/2024 MGI 6.24 |
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