About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fn1tm1.1Sakai
targeted mutation 1.1, Takao Sakai
MGI:5604386
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fn1tm1.1Sakai/Fn1tm1.1Sakai
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5604401


Genotype
MGI:5604401
cn1
Allelic
Composition		 Fn1tm1.1Sakai/Fn1tm1.1Sakai
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fn1tm1.1Sakai mutation (0 available); any Fn1 mutation (130 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal response to injury ( J:214945 )
• pI-pC injected mice show an increase in hepatic stellate cell activation (as indicated by increased alpha-smooth muscle cell actin levels) and elevated production of latent TGF-beta complexes following acute liver injury induced with CCl4, however collagen network formation is normal after injury

liver/biliary system
abnormal liver physiology ( J:214945 )
• pI-pC injected mice show an increase in hepatic stellate cell activation (as indicated by increased alpha-smooth muscle cell actin levels) and elevated production of latent TGF-beta complexes following acute liver injury induced with carbon tetrachloride (CCl4), however collagen network formation is normal after injury




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory