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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adad2em3(IMPC)J
endonuclease-mediated mutation 3, Jackson
MGI:5604765
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adad2em3(IMPC)J/Adad2em3(IMPC)J involves: C57BL/6NJ MGI:6472890


Genotype
MGI:6472890
hm1
Allelic
Composition
Adad2em3(IMPC)J/Adad2em3(IMPC)J
Genetic
Background
involves: C57BL/6NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adad2em3(IMPC)J mutation (0 available); any Adad2 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• no observable spermatozoa in either mutant testis or epididymis
• morphologically abnormal post-meiotic stage 9 germ cells in testis
• dramatically reduced numbers of stage 12 elongating spermatids and presence of what appeared to be large multinucleated cells in testis, suggesting cell death
• absence of elongated spermatids by stage IV

reproductive system
• no observable spermatozoa in either mutant testis or epididymis
• morphologically abnormal post-meiotic stage 9 germ cells in testis
• dramatically reduced numbers of stage 12 elongating spermatids and presence of what appeared to be large multinucleated cells in testis, suggesting cell death
• absence of elongated spermatids by stage IV





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory