Phenotypes associated with this allele

• Allele Symbol: Adad2^em3(IMPC)J
• Allele Name: endonuclease-mediated mutation 3, Jackson
• Allele ID: MGI:5604765
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adad2^em3(IMPC)J/Adad2^em3(IMPC)J	involves: C57BL/6NJ	MGI:6472890

Genotype
MGI:6472890

hm1

• Allelic Composition: Adad2^em3(IMPC)J/Adad2^em3(IMPC)J
• Genetic Background: involves: C57BL/6NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

azoospermia ( J:294176 )

♂ • no observable spermatozoa in either mutant testis or epididymis

abnormal spermatid morphology ( J:294176 )

♂ • absence of elongated spermatids by stage IV

♂ • morphologically abnormal post-meiotic stage 9 germ cells in testis

♂ • dramatically reduced numbers of stage 12 elongating spermatids and presence of what appeared to be large multinucleated cells in testis, suggesting cell death

reproductive system

azoospermia ( J:294176 )

♂ • no observable spermatozoa in either mutant testis or epididymis

abnormal spermatid morphology ( J:294176 )

♂ • morphologically abnormal post-meiotic stage 9 germ cells in testis

♂ • dramatically reduced numbers of stage 12 elongating spermatids and presence of what appeared to be large multinucleated cells in testis, suggesting cell death

♂ • absence of elongated spermatids by stage IV

male infertility ( J:294176 )

♂