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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adad2em3(IMPC)J
endonuclease-mediated mutation 3, Jackson
MGI:5604765
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adad2em3(IMPC)J/Adad2em3(IMPC)J involves: C57BL/6NJ MGI:6472890


Genotype
MGI:6472890
hm1
Allelic
Composition		 Adad2em3(IMPC)J/Adad2em3(IMPC)J
Genetic
Background		 involves: C57BL/6NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adad2em3(IMPC)J mutation (0 available); any Adad2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:294176 )
• no observable spermatozoa in either mutant testis or epididymis
abnormal spermatid morphology ( J:294176 )
• morphologically abnormal post-meiotic stage 9 germ cells in testis
decreased elongated spermatid number ( J:294176 )
• dramatically reduced numbers of stage 12 elongating spermatids and presence of what appeared to be large multinucleated cells in testis, suggesting cell death
• absence of elongated spermatids by stage IV

cellular
azoospermia ( J:294176 )
• no observable spermatozoa in either mutant testis or epididymis
abnormal spermatid morphology ( J:294176 )
• morphologically abnormal post-meiotic stage 9 germ cells in testis
decreased elongated spermatid number ( J:294176 )
• dramatically reduced numbers of stage 12 elongating spermatids and presence of what appeared to be large multinucleated cells in testis, suggesting cell death
• absence of elongated spermatids by stage IV




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory