Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm1(Neurog3*S183A*S187A)Axbe targeted mutation 1, Axel Behrens MGI:5604877 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• beta cells, identified by immunostaining for insulin, occupied a greater proportional area of pancreas sections from adult mice bearing both the conditional Neurog3 knock-in and the embryonically expressed (E9.5-E12.5) pancreatic progenitor cell-specific cre recombinase transgene than in sections from control mice with only the conditional allele (highly significant at p = 0.007 (<= 0.01) by Student's unpaired t test).
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 13 days after tamoxifen injection, a greater proportion of insulin-immunostaining duct cells are observed in pancreas sections from 6-9 week old mice bearing both the conditional Neurog3 knock-in and a pancreatic duct-specific cre recombinase/estrogen receptor fusion knock-in allele than in sections from control mice with only the conditional allele (highly significant at p = 0.0042 (<= 0.01) by Student's unpaired t test).
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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