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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Opa1tm1Lsc
targeted mutation 1, Luca Scorrano
MGI:5605402
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Opa1tm1Lsc/Opa1tm1Lsc involves: C57BL/6J MGI:5605403


Genotype
MGI:5605403
cn1
Allelic
Composition		 Opa1tm1Lsc/Opa1tm1Lsc
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opa1tm1Lsc mutation (0 available); any Opa1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial crista morphology ( J:214492 )
• mice tail vein-injected with Cre-expressing adenoviruses exhibit abnormal liver mitochondria cristae morphology
abnormal mitochondrial physiology ( J:214492 )
• mice tail vein-injected with Cre-expressing adenoviruses exhibit reduced respiratory chain supercomplexes and impaired glutamate/malate respiratory control ratio (an index of respiratory efficiency)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory