All Phenotypes Opa1<tm1Lsc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Opa1^tm1Lsc
targeted mutation 1, Luca Scorrano
MGI:5605402

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Opa1^tm1Lsc/Opa1^tm1Lsc	involves: C57BL/6J	MGI:5605403

Allelic Composition	Opa1^tm1Lsc/Opa1^tm1Lsc
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opa1^tm1Lsc mutation (0 available); any Opa1 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitochondrial crista morphology ( J:214492 )

• mice tail vein-injected with Cre-expressing adenoviruses exhibit abnormal liver mitochondria cristae morphology

abnormal mitochondrial physiology ( J:214492 )

• mice tail vein-injected with Cre-expressing adenoviruses exhibit reduced respiratory chain supercomplexes and impaired glutamate/malate respiratory control ratio (an index of respiratory efficiency)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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